Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Britt ChristensenDavid T Rubin

Abstract

Little is known about the efficacy and safety of induction therapy with calcineurin inhibitors in combination with vedolizumab for patients with Crohn's disease (CD) or ulcerative colitis (UC). We analyzed the outcomes of patients receiving vedolizumab along with calcineurin inhibitors. We collected data on patients with CD (n = 9) or UC (n = 11) who began treatment with vedolizumab from May 20, 2014, through March 30, 2015, and received calcineurin inhibitors (tacrolimus or cyclosporin) during the first 12 months of vedolizumab therapy. Clinical activity scores and inflammatory markers were measured at baseline and at weeks 14, 30, and 52 of vedolizumab treatment. Clinical remission was defined as a Harvey-Bradshaw index score ≤4 or short clinical colitis activity index score ≤2; steroid-free clinical remission was defined as clinical remission without corticosteroids. By week 14 of treatment, 44% of the patients with CD and 55% of the patients with UC achieved steroid-free clinical remission; after 52 weeks of treatment, 33% of the patients with CD and 45% of the patients with UC were in steroid-free clinical remission. Seven patients received salvage therapy with a calcineurin inhibitor after primary nonresponse to vedolizum...Continue Reading

Citations

Jan 27, 2019·Intestinal research·Tomohiro FukudaTakanori Kanai
Mar 7, 2019·The American Journal of Gastroenterology·David T RubinMillie D Long
Oct 28, 2019·Expert Review of Gastroenterology & Hepatology·Rocío SedanoAndres J Yarur
Jan 14, 2020·Journal of Crohn's & Colitis·Steven NicolaidesDaniel R Van Langenberg
Apr 24, 2020·Immunological Medicine·Hiroshi Nakase
Oct 28, 2019·Frontline Gastroenterology·Aravind Gokul TamilarasanMark A Samaan
Jul 19, 2019·United European Gastroenterology Journal·Jurij HanželDavid Drobne
Oct 31, 2018·Advances in Therapy·Roni WeisshofDavid T Rubin
Aug 27, 2019·F1000Research·Mark SamaanSara McCartney
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele
Dec 16, 2020·Inflammatory Bowel Diseases·Sujaata DwadasiDejan Micic
Oct 27, 2020·Therapeutic Advances in Gastroenterology·Ingo GanzlebenRaja Atreya
Mar 24, 2021·Internal and Emergency Medicine·Konstantina Rosiou, Christian Philipp Selinger
Sep 15, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gauthier PelletUNKNOWN Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif
May 18, 2021·Therapeutic Advances in Gastroenterology·Giuseppe PriviteraAlessandro Armuzzi
May 20, 2021·ACG Case Reports Journal·Seth R ShafferDavid T Rubin
Sep 30, 2021·The New England Journal of Medicine·Daniel C Baumgart, Catherine Le Berre

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