Safety and Efficacy of Combined Peptide Receptor Radionuclide Therapy and Liver Selective Internal Radiation Therapy in a Patient With Metastatic Neuroendocrine Tumor

Clinical Nuclear Medicine
M MaccauroE Seregni

Abstract

Nuclear medicine treatments of well-differentiated neuroendocrine tumors (NETs) are gaining increasing acceptance among clinicians. Peptide receptor radionuclide therapy (PRRT) is an effective systemic treatment, providing a significant survival benefit and improving patients' quality of life. Locoregional selective internal radiation therapy (SIRT) is a safe and effective treatment for unresectable NET liver metastases, providing good local tumor control and symptomatic relief. Few reports in literature examine the sequential use of PRRT and SIRT in metastatic NET. We report the case of a metastatic NET patient treated with sequential PRRT-SIRT achieving a long disease control interval without cumulative toxicity issues.

References

Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Sep 19, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Samer EzziddinHojjat Ahmadzadehfar
Nov 16, 2013·European Journal of Nuclear Medicine and Molecular Imaging·E SeregniE Bombardieri
Jul 12, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zlatko DevcicMarnix G E H Lam
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators

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Citations

Feb 14, 2020·Der Radiologe·Rudolf A WernerThorsten Derlin
Aug 30, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rudolf A WernerConstantin Lapa

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