Safety and efficacy of computerized closed-loop delivery of arbutamine: a new pharmacologic myocardial stress modality for the assessment of coronary artery disease. The European Arbutamine Study Group

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
M J CramerC A Visser

Abstract

This study evaluated the efficacy of computer-controlled closed-loop delivery of a new synthetic catecholamine, arbutamine, when given to induce myocardial ischemia detected by electrocardiography and echocardiography with a high (10 beats/min/min) and low (6 beats/min/min) rate of increase in heart rate (heart rate slope) in 70 patients with coronary artery disease. The electrocardiographic sensitivity for the detection of myocardial ischemia was 52% for the low slope and 51% for the high slope. The corresponding figures for echocardiographic sensitivity were 83% and 79% for the low and high slopes, respectively. There were no significant differences in changes from baseline to maximum in pharmacodynamic variables, although the mean times to reach maximum heart rate and systolic blood pressure were 1.4 minutes shorter (p = 0.001) and 3.7 minutes shorter (p < 0.05), respectively, for the high-slope regimen. The duration of the infusion was shorter (p < 0.001) for the high slope. In this study, closed-loop arbutamine administration was effective and safe in the detection of coronary artery disease for both heart rate slope regimens.

References

May 1, 1992·Journal of the American College of Cardiology·P K MazeikaC M Oakley
May 15, 1992·The American Journal of Cardiology·P A Marcovitz, W F Armstrong
Jun 1, 1992·The American Journal of Cardiology·P K MazeikaC M Oakley
Jan 1, 1992·Journal of the American College of Cardiology·T H MarwickE E Salcedo
Feb 15, 1992·The American Journal of Cardiology·F S VillanuevaG A Beller
Nov 1, 1991·Journal of the American College of Cardiology·W A ZoghbiA Trakhtenbroit
Jun 15, 1991·The American Journal of Cardiology·J L CohenC S Kim
May 1, 1989·Progress in Cardiovascular Diseases·J Ross
Sep 1, 1985·The American Journal of Cardiology·E PicanoA L'Abbate
Jan 1, 1984·Journal of Cardiovascular Pharmacology·H H VincentM A Schalekamp
Dec 8, 1983·The New England Journal of Medicine·M J BrownM B Murphy
Jul 1, 1994·Journal of the American College of Cardiology·V L RogerA J Tajik
Jul 1, 1994·Journal of the American College of Cardiology·L J Crouse, P H Kramer
Feb 1, 1994·Journal of the American College of Cardiology·H K Hammond, M D McKirnan
Mar 15, 1993·Journal of the American College of Cardiology·H S HechtR K Myler
Apr 1, 1993·Journal of the American College of Cardiology·P A MarcovitzW F Armstrong
Mar 1, 1993·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T RyanJ A O'Donnell

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