Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species

EFSA Journal
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jordi Tarrés-Call

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on concentrated liquid l-lysine (base) and l-lysine monohydrochloride (HCl) produced using Corynebacterium casei KCCM 80190 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. The production strain is genetically modified. It does not carry acquired antimicrobial resistance genes and no viable cells of the production strain nor its DNA were detected in the final products. Therefore, the additives do not pose any safety concern regarding the genetic modifications. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. casei KCCM 80190 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. Concentrated liquid l-lysine (base) produced by C. casei KCCM 80190 is considered hazardous by inhalation, not irritant to ski...Continue Reading

References

Oct 17, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Laura Martino
Oct 17, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Matteo Lorenzo Innocenti
Oct 17, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Matteo Lorenzo Innocenti
Feb 10, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Robert John Wallace
Mar 28, 2018·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jaume Galobart
Mar 21, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Fernando Ramos
Apr 5, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Giovanna Azimonti
May 2, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Sep 3, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Sep 3, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jordi Tarrés-Call

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Citations

May 8, 2021·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jordi Tarrés-Call
Jul 30, 2021·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jordi Tarrés-Call

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Datasets Mentioned

BETA
KCCM
80190

Methods Mentioned

BETA
genetic
genetic modification
Assay
ion exchange chromatography
IEC

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