PMID: 16506353Mar 2, 2006Paper

Safety and efficacy of eletriptan in the treatment of acute migraine

Pharmacotherapy
Liza TakiyaVeena Kamath

Abstract

Eletriptan is a new selective serotonin agonist approved for the treatment of acute migraine headaches. To review the pharmacologic, pharmacodynamic, pharmacokinetic, safety, and clinical efficacy data for eletriptan, we searched the literature in PubMed/MEDLINE, EMBASE, International Pharmaceutical Abstracts, and Science Direct databases to gather all published reports from January 1996-October 2004. All English-language reports (abstract or full trial reports) about the pharmacology, pharmacokinetics, clinical efficacy, and safety of eletriptan were reviewed. Eletriptan's pharmacokinetic and pharmacodynamic parameters translate into a favorable safety and efficacy profile. The drug is rapidly absorbed when administered orally, has good bioavailability and central nervous system penetration due to its lipophilicity, and has a long half-life, which contributes to its ability to prevent recurrent headaches. Compared with other serotonin agonists, eletriptan has a longer duration of action and greater lipophilicity. Eletriptan is metabolized through the cytochrome P450 3A4 system; therefore, it does have the potential for clinically significant drug interactions. In clinical trials, eletriptan demonstrated efficacy superior to th...Continue Reading

References

Jan 1, 1992·JAMA : the Journal of the American Medical Association·W F StewartM L Reed
Apr 18, 1998·Lancet·M D Ferrari
Mar 19, 1999·Acta Psychiatrica Scandinavica·J K Larsen
Apr 29, 1999·Archives of Internal Medicine·X H HuM L Berger
Aug 3, 1999·Clinical Pharmacology and Therapeutics·D F MuirW S Hillis
Aug 24, 1999·Pharmacotherapy·K W WeitzelJ V Goode
Aug 27, 1999·Journal of Neurology·H C DienerV Limmroth
Oct 26, 2000·European Journal of Pharmacology·R W van den BroekP R Saxena
Feb 13, 2001·Cephalalgia : an International Journal of Headache·E J Dasbach Kramer
Mar 3, 2001·PharmacoEconomics·N E Wells, T J Steiner
Aug 2, 2001·The Medical Clinics of North America·S J Tepper
Sep 18, 2001·Archives of Neurology·A M Rapoport, S J Tepper
May 23, 2002·Journal of Clinical Pharmacology·Ajit K ShahJoel Morganroth
Oct 18, 2002·Cephalalgia : an International Journal of Headache·M D FerrariR B Lipton
Oct 23, 2002·Neurology·G SandriniUNKNOWN Eletriptan Steering Committee
Feb 27, 2003·Headache·Ninan T MathewCarolyn R Sikes
Jun 17, 2003·Cephalalgia : an International Journal of Headache·M FärkkiläC Sikes
Jul 16, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nicholas WellsFrancis Pang
Nov 18, 2003·Cephalalgia : an International Journal of Headache·G Garcia-RamosJ Hettiarachchi
Feb 27, 2004·Cephalalgia : an International Journal of Headache·T J SteinerC R Sikes
Jun 16, 2004·Cephalalgia : an International Journal of Headache·J A GoldsteinN C Jackson

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Citations

May 11, 2007·Expert Review of Cardiovascular Therapy·Glaucia CalleraRhian M Touyz
Nov 28, 2006·Expert Opinion on Drug Metabolism & Toxicology·Emilio SternieriAnna Ferrari
Dec 15, 2010·Expert Opinion on Drug Metabolism & Toxicology·Giovanna GentilePaolo Martelletti
Mar 14, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Daniele VandelliEnrico Silingardi
Sep 2, 2016·Therapeutic Advances in Neurological Disorders·Matilde CapiPaolo Martelletti
Apr 11, 2020·Expert Opinion on Drug Metabolism & Toxicology·Akin CayirMunevver Coskun
Apr 20, 2016·Journal of Materials Science. Materials in Medicine·Santosh ShelkeHemlata Patil
Jun 20, 2018·The Journal of Organic Chemistry·Berrak ErtugrulNurullah Saracoglu

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