Jan 20, 2006

Safety and efficacy of escitalopram in the long-term treatment of generalized anxiety disorder

The Journal of Clinical Psychiatry
Jonathan R T DavidsonQin Wang


Generalized anxiety disorder (GAD) is a chronic disorder that requires long-term treatment. Escitalopram has previously been shown to be effective and well tolerated in the acute treatment of GAD. Three 8-week, double-blind, placebo-controlled trials of nearly identical design were conducted of escitalopram in moderate-to-severe GAD (DSM-IV criteria). Patients completing these trials were given the option of entering a 24-week, open-label, flexible-dose trial of escitalopram (10-20 mg/day). Data were collected from September 20, 2000, to August 15, 2002. Two hundred ninety-nine (56.8%) of 526 patients completed 24 weeks of open-label treatment. The mean Hamilton Rating Scale for Anxiety (HAM-A) score at baseline of open-label treatment was 13.1. Long-term escitalopram treatment led to continuing improvement on all anxiety and quality-of-life (QOL) scores. Of those completing 24 weeks of treatment, 92.0% were responders (Clinical Global Impressions-Improvement scale score < or = 2), and the mean HAM-A score in the completed analysis was 6.9; using the last observation carried forward (LOCF), 75.9% were responders, and the mean HAM-A score in the LOCF analysis was 9.2 at endpoint. Insufficient therapeutic response and adverse eve...Continue Reading

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Mentioned in this Paper

Diagnostic and Statistical Manual of Mental Disorders
Chronic Disease
Adverse Event
Longitudinal Survey
Urgent Care
Anxiety Disorders
Selective Serotonin Reuptake Inhibitors
Anxiety States, Neurotic
Factor Construct Rating Scales (Fcrs)

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