Safety and Efficacy of Exercise Training in Patients With an Implantable Cardioverter-Defibrillator: A Meta-Analysis

JACC. Clinical Electrophysiology
Ambarish PandeyJarett Berry

Abstract

In this study, the authors performed a meta-analysis of currently available comparative prospective studies to assess the efficacy and safety of exercise training in heart failure (HF) patients with implantable cardioverter-defibrillators (ICD). ICDs have been shown to improve survival in patients with HF. However, many patients with ICDs experience fear of shocks and avoid physical activity. Few data exist for efficacy and safety of exercise training in HF patients with ICDs. Prospective parallel arm trials with control and exercise training groups that evaluated the efficacy of exercise training in patients with ICDs were included in the meta-analysis. Outcomes of interest were difference in the change in cardiorespiratory fitness (CRF) (ml/kg/min) between exercise and control group and the likelihood of ICD shocks among exercise training compared with that among control participants on follow-up. We included study level data from 6 trials (5 randomized controlled trials and 1 nonrandomized controlled trial). In the pooled analysis, ICD patients undergoing exercise training had significant improvement in CRF (weighted mean difference: 1.98 ml/kg/min; 95% confidence interval [CI]: 0.58 to 3.38). The likelihood of ICD shocks on...Continue Reading

References

Jan 18, 2002·Journal of Applied Physiology·George E Billman
May 12, 2004·Heart & Lung : the Journal of Critical Care·Jim LemonAnn Kirkness
Oct 11, 2005·Archives of Physical Medicine and Rehabilitation·Jennifer S DavidsRachel Lampert
Jan 24, 2006·Journal of Cardiovascular Electrophysiology·Rachel LampertBrian Olshansky
Sep 27, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Romualdo BelardinelliDemetrios Georgiou
Apr 9, 2009·JAMA : the Journal of the American Medical Association·Christopher M O'ConnorUNKNOWN HF-ACTION Investigators
Apr 9, 2009·JAMA : the Journal of the American Medical Association·Kathryn E FlynnUNKNOWN HF-ACTION Investigators
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Oct 19, 2010·Journal of the American College of Cardiology·Jari A LaukkanenSudhir Kurl
Feb 8, 2014·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Selina Kikkenborg BergJesper H Svendsen
Jun 27, 2015·Journal of the American College of Cardiology·Rajeev K PathakPrashanthan Sanders

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Citations

May 19, 2018·Journal of the American Heart Association·Lindsey RosmanMatthew M Burg
Feb 13, 2019·The Cochrane Database of Systematic Reviews·Kim M NielsenSelina K Berg
Aug 10, 2019·Journal of Cardiopulmonary Rehabilitation and Prevention·Daniel A SteinhausDaniel B Kramer
Jun 4, 2020·Arquivos brasileiros de cardiologia·Tales de CarvalhoSalvador Manoel Serra

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