Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study

Arthritis & Rheumatology
Alice TisonGroupe de Cancérologie Cutanée, Groupe Français de Pneumo-Cancérologie, and Club Rhumatismes et Inflammations

Abstract

Immune checkpoint inhibitors (ICIs) for cancer therapy frequently induce immune-related adverse effects (IRAEs). Therefore, most patients with preexisting autoimmune diseases have been excluded from clinical trials of ICIs. This study was undertaken to evaluate the safety and efficacy of ICIs in patients with preexisting autoimmune disease and cancer. A retrospective cohort study was conducted from January 2017 to January 2018 via 3 French national networks of experts in oncology and autoimmunity. Adults with preexisting autoimmune disease who were receiving ICIs were assessed for the occurrence of flare of preexisting autoimmune disease, other IRAEs, and cancer response. The study included 112 patients who were followed up for a median of 8 months. The most frequent preexisting autoimmune diseases were psoriasis (n = 31), rheumatoid arthritis (n = 20), and inflammatory bowel disease (n = 14). Twenty-four patients (22%) were receiving immunosuppressive therapy at ICI initiation. Autoimmune disease flare and/or other IRAE(s) occurred in 79 patients (71%), including flare of preexisting autoimmune disease in 53 patients (47%) and/or other IRAE(s) in 47 patients (42%), with a need for immunosuppressive therapy in 48 patients (43%)...Continue Reading

References

Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter AttiaSteven A Rosenberg
Nov 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie G DowneySteven A Rosenberg
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Dec 28, 2010·Current Opinion in Immunology·Thomas F GajewskiJustin Kline
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Sep 18, 2014·Cancer Immunology, Immunotherapy : CII·Magnus PedersenInge Marie Svane
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hansje-Eva TeulingsRosalie M Luiten
Apr 22, 2015·The New England Journal of Medicine·Paul B ChapmanJedd D Wolchok
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M MichotO Lambotte
Feb 11, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B LeeS Sandhu
Jul 2, 2016·JAMA Oncology·Claire F FriedmanMichael A Postow
Aug 28, 2016·Annals of the Rheumatic Diseases·Leonard Calabrese, Vamsidhar Velcheti
Sep 9, 2016·Brain : a Journal of Neurology·Lidia M YshiiRoland Liblau
Sep 11, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Saskia HerzCindy Franklin
Oct 1, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M MenziesG V Long
Oct 16, 2016·Advances in Chronic Kidney Disease·Umberto Maggiore, Julio Pascual
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberCaroline Robert
Feb 19, 2017·La Revue de médecine interne·M KostineC Stavris
Feb 20, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ralf GutzmerUNKNOWN German Dermatooncology Group (DeCOG)
Feb 28, 2017·Cancer·Douglas B JohnsonAlexander M Menzies
Apr 7, 2017·Gastroenterology·Enrico N De Toni, Alexander L Gerbes
May 18, 2017·The New England Journal of Medicine·Khashayar Esfahani, Wilson H Miller
Jun 11, 2017·Annals of the Rheumatic Diseases·Rakiba BelkhirXavier Mariette
Aug 26, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk SchadendorfMichael A Postow
Sep 9, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J B A G HaanenUNKNOWN ESMO Guidelines Committee
Dec 7, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Chipman Rg StroudPaul Walker
Jan 15, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·François-Xavier DanlosOlivier Lambotte
Jan 25, 2018·Arthritis & Rheumatology·Michael D RichterUma Thanarajasingam
Mar 1, 2018·Cancer Immunology, Immunotherapy : CII·Katharina C KählerUNKNOWN German Dermatologic Cooperative Oncology Group (DeCOG)
May 11, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giulia C LeonardiMark M Awad
Aug 21, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn C ArbourMatthew D Hellmann

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Citations

Aug 6, 2019·Arthritis & Rheumatology·Lenore M Buckley, Maria E Suarez-Almazor
Jan 19, 2020·International Journal of Molecular Sciences·Sanna Iivanainen, Jussi P Koivunen
Mar 14, 2020·Current Opinion in Rheumatology·Susanna Jeurling, Laura C Cappelli
Apr 19, 2020·Journal for Immunotherapy of Cancer·Patrick BolandSabina Sandigursky
May 3, 2020·International Journal of Molecular Sciences·Antonio G SolimandoVito Racanelli
Jun 26, 2020·JCO Oncology Practice·Zimu Gong, Yinghong Wang
Jun 17, 2020·Diabetes/metabolism Research and Reviews·Zhenjiang ZhengXubao Liu
Jul 29, 2020·Current Treatment Options in Oncology·Puneet SaxenaNavneet Singh
May 10, 2020·Nature Reviews. Disease Primers·Manuel Ramos-CasalsMaria E Suárez-Almazor
Aug 22, 2020·World Journal of Gastroenterology : WJG·Yezaz A GhouriBo Shen
Feb 23, 2020·Asia-Pacific Journal of Clinical Oncology·Bei TanJiaming Qian
Aug 4, 2020·Rheumatology International·Foteini AngelopoulouDimitrios Daoussis
Aug 5, 2020·Gut·Matthias PinterMarkus Peck-Radosavljevic
Jul 31, 2020·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Mar 21, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J HaanenM Obeid
Nov 20, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mihaela AldeaJean-Marie Michot
Oct 23, 2020·Vaccines·Mohamed A Abd El AzizRodolfo Sacco
Dec 20, 2019·Genes & Diseases·Xianghu JiangYunbao Pan
Dec 18, 2020·Frontiers in Oncology·Tomasz KubiatowskiPaweł Krawczyk
Dec 11, 2020·The Cancer Journal·Mitchell S von ItzsteinDavid E Gerber
Mar 2, 2021·Immunotherapy·Sang T KimMaria E Suarez-Almazor
Nov 14, 2020·Arthritis & Rheumatology·Laura C Cappelli, Clifton O Bingham
Feb 23, 2021·Frontiers in Cardiovascular Medicine·Shirley XuSaraswati Pokharel
Mar 9, 2021·Journal of Immunology Research·Rangarirai MakukuNima Rezaei
Mar 23, 2021·Expert Opinion on Drug Safety·Remo PotoGilda Varricchi
Mar 28, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K RzeniewiczS Turajlic
Nov 19, 2020·JHEP Reports : Innovation in Hepatology·Eleonora De MartinDidier Samuel
Apr 28, 2021·Bulletin du cancer·Thomas TingryCyrille B Confavreux
May 9, 2021·Journal for Immunotherapy of Cancer·Lauren J BrownMatteo S Carlino

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