Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial

International Journal of Cardiology
Xinyang HuJian'an Wang

Abstract

Pre-clinical studies have shown that hypoxia preconditioning can enhance stem cell therapeutic potential for myocardial repair. We sought to investigate the safety and feasibility of intracoronary administration of hypoxia-preconditioned bone marrow mononuclear cells (HP-BMCs) for acute ST segment elevation myocardial infarction (STEMI). We randomized 22 patients with acute STEMI to receive intracoronary administration of normoxia bone marrow mononuclear cells (N-BMCs) (n=11) or HP-BMCs (n=11) following successful reperfusion. Another 14 patients receiving standard therapy were recruited as control (n=14). There were no differences in the occurrence of major adverse cardiovascular events at 30 days and 1 year among three groups. There were significant improvement in the change of left ventricular end-diastolic volume (LVEDV) and end-systolic volume (LVESV) in HP-BMC group both at 6 and 12 months compared with N-BMCs or control group (P<0.05). No differences were observed in the change of left ventricular ejection fraction (LVEF), or wall motion score index (WMSI) among three groups. Nevertheless, WMSI was improved in HP-BMCs and N-BMC group (P<0.05, within group), but not in control. The ratio of myocardial perfusion defect det...Continue Reading

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Citations

Feb 7, 2017·British Medical Bulletin·Hong YuJian'an Wang
Feb 27, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrizia NigroGiulio Pompilio
May 31, 2017·Human Gene Therapy·Francesco Albert Bosco CorteseGiovanni Santostasi
Oct 1, 2017·Circulation Research·Jun JiangJian'an Wang
Jun 28, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Dimitrios Tsiapalis, Dimitrios I Zeugolis
Oct 1, 2015·The Cochrane Database of Systematic Reviews·Sheila A FisherEnca Martin-Rendon
Jan 10, 2017·International Journal of Molecular Sciences·Liangfu JiangXiaofeng Jia
Sep 5, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Akon HiguchiKadarkarai Murugan
Jan 10, 2019·Stem Cells International·Zhi ChenWei Eric Wang
Feb 8, 2020·Cardiology in Review·Joseph Rudman, William H Frishman
Feb 13, 2021·Frontiers in Cardiovascular Medicine·Weili ShiKeji Chen

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