Safety and efficacy of IV treprostinil for pulmonary arterial hypertension: a prospective, multicenter, open-label, 12-week trial

Chest
Victor F TapsonRobyn J Barst

Abstract

Pulmonary arterial hypertension (PAH) is a life-threatening disease for which both continuous IV epoprostenol and continuous subcutaneous treprostinil have proven effective. With continuous IV treprostinil having potential advantages over both of the above therapies, we investigated the safety and efficacy of this regimen in patients with PAH. We conducted a 12-week, prospective, open-label, uncontrolled, multicenter study of continuous IV treprostinil in 16 patients with PAH that was idiopathic (n = 8), related to connective tissue disease (n = 6), or related to congenital heart disease (n = 2). The primary end point was change from baseline to week 12 in exercise capacity assessed by the 6-min walk (6MW) test. Continuous IV treprostinil increased 6MW distance (mean +/- SE) by 82 m from baseline (319 +/- 22 m) to week 12 (400 +/- 26 m) [n = 14; p = 0.001]. There were also significant improvements in the secondary end points of Naughton-Balke treadmill time (p = 0.007), Borg dyspnea score (p = 0.008), and hemodynamics (mean pulmonary artery pressure, p = 0.03; cardiac index, p = 0.002; pulmonary vascular resistance, p = 0.001) at week 12 compared with baseline. Side effects were mild and consistent with those reported with pros...Continue Reading

References

Aug 1, 1987·Annals of Internal Medicine·S RichS K Koerner
Feb 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M J McNultyR P Steffen
Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
Jan 9, 1997·The New England Journal of Medicine·L J Rubin
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Gerald SimonneauUNKNOWN Treprostinil Study Group
Sep 3, 2002·Journal of the American College of Cardiology·Olivier SitbonGérald Simonneau
Sep 18, 2002·Circulation·Vallerie V McLaughlinStuart Rich
Jun 15, 2004·Journal of the American College of Cardiology·Gerald SimonneauAlfred Fishman

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Citations

Apr 25, 2009·Indian Journal of Pediatrics·Erika B Rosenzweig, Robyn J Barst
Apr 2, 2011·Advances in Therapy·Jean-Luc Vachiéry
May 25, 2007·Nature Clinical Practice. Cardiovascular Medicine·Aniket PuriSudhir S Kushwaha
Aug 12, 2009·Current Opinion in Rheumatology·Stephen C Mathai, Paul M Hassoun
Apr 17, 2010·Cardiology in Review·Joe R Anderson, James J Nawarskas
May 14, 2008·Current Opinion in Pediatrics·Erika B Rosenzweig, Robyn J Barst
Nov 20, 2008·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Aimee DoranBrett Goetz
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Steven H Abman
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·D Dunbar Ivy
Jul 22, 2008·International Journal of Clinical Practice. Supplement·A K DoranUNKNOWN Scientific Leadership Council of the Pulmonary Hypertension Association
Apr 9, 2010·International Journal of Rheumatic Diseases·Geoff Strange, Peter Nash
Dec 4, 2012·American Journal of Respiratory and Critical Care Medicine·Ralf EwertHossein Ardeschir Ghofrani
Mar 2, 2011·The European Respiratory Journal·R J BarstD D Ivy
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Rajendrakumar PatelSumir P Sahgal
Feb 1, 2012·Drug Design, Development and Therapy·Richard N ChannickLewis J Rubin
Dec 31, 2010·Vascular Health and Risk Management·Samuel T Nadler, Jeffrey D Edelman
May 19, 2010·Vascular Health and Risk Management·Jeremy A FalkErnst R Schwarz
Aug 12, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Nika Skoro-Sajer, Irene Lang
Dec 13, 2006·Treatments in Respiratory Medicine·Amira A Shahin
Sep 1, 2009·Clinical Drug Investigation·Margaret C GarinKristin B Highland
Aug 9, 2012·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Shireen Mirza, Raymond J Foley
Feb 22, 2012·Indian Journal of Pharmacology·Sandeep ChopraDavis Cherian
Oct 3, 2013·Journal of Cardiovascular Pharmacology·Laith AlkukhunAdriano R Tonelli
Aug 1, 2014·Annals of Thoracic Medicine·Majdy M IdreesRober D Levy
Dec 17, 2008·Journal des maladies vasculaires·C AgardM-A Hamidou
May 2, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Adriano R TonelliRaed A Dweik
Oct 12, 2014·Current Hypertension Reports·Aaron M WolfsonMardi Gomberg-Maitland
Nov 8, 2014·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Martha S Kingman, Sandra Lombardi
May 2, 2007·Current Cardiology Reports·Mobusher Mahmud, Hunter C Champion
Apr 22, 2010·Current Opinion in Supportive and Palliative Care·Dimitar SajkovPaolo Palange
Jan 2, 2007·Critical Care Nursing Quarterly·Glenna L Traiger
Oct 21, 2006·Current Opinion in Cardiology·B K S Sastry
Nov 4, 2009·Expert Review of Respiratory Medicine·Paul M Hassoun
Nov 5, 2014·Expert Review of Cardiovascular Therapy·Nika Skoro-Sajer, Irene Lang
Jul 14, 2012·Expert Review of Respiratory Medicine·Barbara L LeVarge, Richard N Channick
Oct 13, 2011·Expert Opinion on Pharmacotherapy·Matthew Ferrantino, R James White
Dec 25, 2012·Expert Review of Cardiovascular Therapy·Fernando Torres, Lewis J Rubin
May 14, 2008·Expert Opinion on Pharmacotherapy·Nika Skoro-Sajer, Irene Lang
Feb 25, 2009·Expert Opinion on Drug Metabolism & Toxicology·Wouter Jacobs, Anton Vonk-Noordegraaf
Dec 14, 2007·Expert Opinion on Pharmacotherapy·James A Driscoll, Murali M Chakinala
Jan 26, 2010·Expert Opinion on Emerging Drugs·Reda E Girgis

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