Safety and efficacy of kunzea oil-containing formulations for the management of psoriasis: a randomized, controlled trial

Journal of Clinical Pharmacy and Therapeutics
J ThomasG M Peterson

Abstract

Anecdotally, topical kunzea oil has been used to treat various skin conditions, including psoriasis and eczema, with good results. This study compared the clinical efficacy of kunzea oil (20%)-containing formulations in mild to moderate psoriasis. A randomized, comparative, double-blind, 8-week study was undertaken. Thirty patients (age range: 25-74 years and mean ± SD: 52·8 ± 13·6 years) with mild to moderate psoriasis (affecting at least 10% of one or more body regions: arms, head, legs and trunk) randomly received ointment and/or scalp lotion containing 20% kunzea oil (test group) or control medications not containing kunzea oil (control group). Formulations in both treatment arms also contained 5% liquor carbonis detergens (LCD) and 3% salicylic acid. The clinical responses to the test and control formulations were evaluated using the Psoriasis Area and Severity Index (PASI). After 8 weeks of treatment, both test and control groups demonstrated a significant (P < 0·05) improvement in PASI scores. Subjects in the test group had a decrease in mean±SD PASI score from 12·7 ± 7·9 to 6·7 ± 7·2, whereas the control group showed a decrease in PASI score from 8·1 ± 4·6 to 3·5 ± 4·7. Comparative efficacy analysis between the test and...Continue Reading

References

Nov 1, 1994·The British Journal of Dermatology·S N ThamW K Cheong
Sep 1, 1993·The British Journal of Dermatology·M H Kanzler, D C Gorsulowsky
Aug 1, 1996·Tropical Medicine & International Health : TM & IH·T A SyedM Afzal
Aug 7, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·P C van de KerkhofM V Kuipers
Jan 5, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·P C van de KerkhofM V Kuipers
Mar 5, 1999·International Journal of Dermatology·M Lebwohl
May 11, 1999·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·T TeruiH Tagami
Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·D M AshcroftC E Griffiths
Oct 5, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·M StückerP Altmeyer
Jan 10, 2002·Clinical Microbiology Reviews·H Ruth Ashbee, E Glyn V Evans
Aug 16, 2003·Dermatologic Therapy·Giovanni Luigi Capella, Aldo F Finzi
Nov 25, 2003·The New England Journal of Medicine·Craig L LeonardiUNKNOWN Etanercept Psoriasis Study Group
Nov 4, 2004·Journal of the American Academy of Dermatology·Aditya K GuptaThomas L Dawson
Aug 17, 2005·International Journal of Dermatology·Amy C BrownSerena Lo
Jan 19, 2006·Clinical Microbiology Reviews·C F CarsonT V Riley
Nov 21, 2007·Clinics in Dermatology·Robert SabatKerstin Wolk
Feb 5, 2010·The British Journal of Dermatology·J RenneM Wittmann
Nov 29, 2011·Dermatologic Clinics·Kai Li, April W Armstrong
Nov 29, 2011·Indian Journal of Dermatology·Maryam GhiasiKeramat Nourijelyani
Apr 5, 2012·Skin Pharmacology and Physiology·Nader Pazyar, Reza Yaghoobi
Sep 28, 2012·The Journal of Investigative Dermatology·Rosa ParisiUNKNOWN Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
Feb 19, 2013·The British Journal of Dermatology·E J SamarasekeraC H Smith
Jul 24, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Steven R FeldmanUsha G Mallya

❮ Previous
Next ❯

Citations

Dec 7, 2021·Journal of Cosmetic Dermatology·Cassandra CunhaAndré R T S Araujo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.