Safety and Efficacy of l-histidine monohydrochloride monohydrate produced by fermentation using Escherichia coli KCCM 80212 as a feed additive for all animal species

EFSA Journal
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jordi Tarrés-Call

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-histidine monohydrochloride (HCl) monohydrate produced by fermentation using Escherichia coli KCCM 80212 when used as a nutritional additive in feed for all animal species. The production strain is genetically modified. The production strain and its recombinant DNA were not detected in the final product. l-Histidine HCl monohydrate manufactured by fermentation using E. coli KCCM 80212 does not give rise to any safety concern regarding the genetic modification. The use of l-histidine HCl monohydrate produced by fermentation using E. coli KCCM 80212 is safe for the target species when used as a nutritional additive to supplement the diet in appropriate amounts to cover the requirements, depending on the species, the physiological state of the animal, the performance level, the environmental conditions, the background amino acid composition of the unsupplemented diet and the status of some essential trace elements such as copper and zinc. l-Histidine HCl monohydrate produced using E. coli KCCM 80212 supplemented at levels appropriate for the requirements of ...Continue Reading

References

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Oct 17, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Laura Martino
Oct 17, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Matteo Lorenzo Innocenti
Oct 17, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Matteo Lorenzo Innocenti
Mar 28, 2018·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jaume Galobart
May 7, 2018·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Laura Martino
Apr 5, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Giovanna Azimonti
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fabiola Pizzo

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Datasets Mentioned

BETA
KCCM
80212

Methods Mentioned

BETA
genetic modifications
genetic modification
IEC

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