Safety and Efficacy of Landiolol Hydrochloride in Children with Tachyarrhythmia of Various Etiologies.

Pediatric Cardiology
Atsuko AshidaAkira Ashida

Abstract

The safety and efficacy of landiolol have not been fully elucidated in pediatric patients. This study aimed to clarify the safety and efficacy of landiolol in a pediatric cohort. We retrospectively assessed the clinical features of 21 pediatric patients who were administered landiolol at our hospital. We also investigated the rates of sinus rhythm conversion and heart rate response. The median patient age was 7 months (interquartile range 1-13 months). The etiology of tachyarrhythmia was junctional ectopic tachycardia in 10 patients (47.6%), atrial tachycardia in 10 patients (47.6%), and ventricular tachycardia in 1 patient (4.8%). Of the 21 children, 18 (85.7%) had congenital heart defects, including 14 (77.8%) in whom a landiolol infusion was performed perioperatively. The landiolol infusion was effective in 18 pediatric patients (85.7%), as measured by the conversion to sinus rhythm or a reduced heart rate. Atrial tachycardia in the perioperative period was terminated in all patients. Of 7 patients with tachyarrhythmias unrelated to the perioperative period, landiolol was effective in 5. No adverse effects were reported in any patient. Landiolol infusion is effective and safe in pediatric patients with tachyarrhythmia of var...Continue Reading

References

Jun 1, 1992·Chemical & Pharmaceutical Bulletin·S IguchiM Kawamura
Jun 1, 1991·Clinical Pharmacology and Therapeutics·D B WiestS S Garner
Jul 1, 1991·The Journal of Pediatrics·D L TrippelP C Gillette
Jul 1, 1989·Journal of the American College of Cardiology·J C PerryA Garson
Oct 1, 1995·Journal of the American College of Cardiology·J P PfammatterH C Kallfelz
Feb 2, 2002·Journal of the American College of Cardiology·Jack F PriceArnold L Fenrich
Aug 16, 2012·General Thoracic and Cardiovascular Surgery·Tomomi HasegawaRei Noda
Mar 9, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hirofumi SaikiHideaki Senzaki
Mar 20, 2013·The Annals of Thoracic Surgery·Chiho TokunagaYuzuru Sakakibara
Mar 19, 2015·Cardiology in the Young·Hideharu OkaHiroshi Azuma
Apr 13, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Shuhei FujitaKiyoshi Hatasaki
Apr 21, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Fumiya YoneyamaYuji Hiramatsu

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