Safety and Efficacy of Liposomal Cytarabine in the Treatment of Neoplastic Meningitis

Oncology
Franziska JahnBerit Jordan

Abstract

Although rare, neoplastic meningitis (NM) has been increasingly observed in patients with cancer due to the prolonged course of the disease. Intrathecal chemotherapy with methotrexate or cytarabine with repeating injection schedules of 2-3 times per week is currently the mainstay of treatment. An efficacious and comfortable treatment alternative might be represented by liposomal cytarabine. In this retrospective study, we reviewed all patients with NM due to solid tumors or hematological malignancies treated with liposomal cytarabine at our institution between March 2004 and September 2011. The primary endpoint was treatment response, which was defined as improvement in neurological symptoms and/or conversion of the initial cerebrospinal fluid cytology and/or response in the radiological findings. The main secondary endpoint was safety. Fifty-one adult patients were evaluable for safety and 44 patients for efficacy. In 36 patients (81.8%), a treatment response was achieved. The median overall survival after diagnosis of NM was 11 months (95% confidence interval 8.8-13.2). Adverse events grade 1-4 occurred in 31 patients (60.8%), whereas grade 3-4 occurred in 18 patients (35.3%). The encouraging efficacy and safety data obtained...Continue Reading

Citations

Dec 10, 2015·Frontiers in Pharmacology·Lisa SercombeSusan Hua
Jun 29, 2016·Expert Opinion on Drug Delivery·Tessa van der GeestOtto C Boerman
Dec 27, 2017·Current Medical Research and Opinion·Nasimudeen R JabirShams Tabrez
Nov 3, 2016·Current Opinion in Neurology·Emilie Le Rhun, Evanthia Galanis
Aug 18, 2018·Cancer Chemotherapy and Pharmacology·Isabel SousaPaula Soares
Mar 7, 2020·Advanced Drug Delivery Reviews·M J FowlerR W Sirianni
Aug 31, 2021·Current Pharmaceutical Design·Bapi GorainHira Choudhury

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Cell Invasion: Nanomedicine

Nanomedicine is a promising alternative for cancer detection and therapy that utilizes nanoparticles, such as liposomes. Nanoparticles can potentially target cancer cell invasion and metastasis. Discover the latest research on Cancer Cell Invasion: Nanomedicine here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.