Safety and efficacy of long-term co-administration of fenofibrate and ezetimibe in patients with mixed hyperlipidemia

Journal of the American College of Cardiology
James M McKenneyBarry Gumbiner

Abstract

This study sought to determine the long-term safety and efficacy of co-administered fenofibrate (FENO) and ezetimibe (EZE) in patients with mixed hyperlipidemia. Both EZE and FENO offer complementary benefits to the lipid profile of patients with mixed hyperlipidemia. After completing the 12-week randomized, double-blind base study that compared EZE 10 mg, FENO 160 mg, FENO 160 mg plus EZE 10 mg, and placebo in patients with mixed hyperlipidemia, patients continued into a double-blind, 48-week extension phase. Those patients in the FENO plus EZE and FENO groups continued on their respective base study treatment, and patients in the EZE and placebo groups were switched to FENO plus EZE and FENO, respectively. Of the 587 patients who completed the base study, 576 continued into the extension study (n = 340 in FENO plus EZE and n = 236 in FENO). The FENO plus EZE produced significantly greater reductions in low-density lipoprotein-cholesterol compared with FENO (-22% vs. -9%, respectively; p < 0.001). There were also significantly greater improvements in triglycerides, high-density lipoprotein cholesterol (HDL-C), total cholesterol, non-HDL-C, and apolipoprotein B with FENO plus EZE compared with FENO. Changes in apolipoprotein A-...Continue Reading

References

Aug 1, 1990·Seminars in Liver Disease·C SamaL Barbara
Nov 9, 2002·The American Journal of Cardiology·Carlos A DujovneUNKNOWN Ezetimibe Study Group
Mar 17, 2004·Current Atherosclerosis Reports·Sergio Fazio, MacRae F Linton
Mar 23, 2005·European Heart Journal·Michel FarnierUNKNOWN Ezetimibe Study Group

❮ Previous
Next ❯

Citations

Oct 19, 2010·Pharmaceutical Research·Yuki IwayanagiHiroshi Suzuki
Jul 25, 2009·Current Treatment Options in Cardiovascular Medicine·William H Smiley IIILaurence S Sperling
Jan 24, 2007·American Heart Journal·Michel FarnierUNKNOWN Ezetimibe/Simvastatin + Fenofibrate Study Group
Oct 26, 2006·Nature Clinical Practice. Cardiovascular Medicine·Michael H Davidson
Dec 2, 2010·Metabolic Syndrome and Related Disorders·Harold E BaysBarry Gumbiner
Apr 17, 2008·Cardiology in Review·Joshua RemickArthur Schwartzbard
Nov 22, 2011·Current Opinion in Lipidology·Harry R DavisThomas Musliner
Jul 25, 2007·Diabetes, Obesity & Metabolism·A S Wierzbicki
Jan 5, 2008·International Journal of Clinical Practice·M FlorentinM S Elisaf
Nov 26, 2010·International Journal of Clinical Practice·T A Jacobson
Feb 22, 2008·PPAR Research·Jennifer G Robinson
Apr 11, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·George YuanRobert A Hegele
Jul 23, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Marcello Arca, Giovanni Pigna
Aug 12, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Karim El HarchaouiJohn J P Kastelein
Sep 29, 2011·Drugs·Kate McKeage, Gillian M Keating
Jul 2, 2008·Internal Medicine·Shin-ichiro Miura, Keijiro Saku
Mar 26, 2013·Nutrients·Amanda Brahm, Robert A Hegele
Jun 15, 2010·Journal of Atherosclerosis and Thrombosis·José C SandovalShizuya Yamashita
Aug 1, 2007·Biomarkers in Medicine·David Conen, Paul M Ridker
Jun 6, 2009·QJM : Monthly Journal of the Association of Physicians·M Miller
Nov 16, 2006·Expert Opinion on Therapeutic Targets·Irene F Gazi, Dimitri P Mikhailidis
Nov 21, 2008·Expert Review of Cardiovascular Therapy·Robert S Rosenson
Mar 29, 2011·Expert Review of Cardiovascular Therapy·Aris P AgouridisMoses S Elisaf
Jun 10, 2008·Expert Opinion on Emerging Drugs·Rebecca L PollexRobert A Hegele
Mar 23, 2011·Expert Opinion on Drug Safety·Michel Farnier
May 24, 2007·Current Medical Research and Opinion·Mihalis KalogirouMoses Elisaf
Feb 16, 2010·European Journal of Pharmacology·Michalis KalogirouMoses Elisaf
Nov 26, 2008·Atherosclerosis·Manfredi RizzoKaspar Berneis
Oct 1, 2008·Journal of Clinical Lipidology·Hanna Slim, Paul D Thompson
Aug 25, 2015·International Journal of Cardiology·Gianluigi SavaresePasquale Perrone-Filardi
Mar 8, 2008·Journal of Internal Medicine·C P Cannon
Feb 21, 2008·The Journal of Pharmacy and Pharmacology·Si-Yuan PanKam-Ming Ko
Mar 21, 2007·The American Journal of Cardiology·Peter P Toth
Mar 21, 2007·The American Journal of Cardiology·Michael H DavidsonTerry A Jacobson
Apr 1, 2015·Journal of Cellular Biochemistry·Alain SanéEmile Levy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.