Safety and efficacy of moxifloxacin-dexamethasone eyedrops as treatment for bacterial ocular infection associated with bacterial blepharitis

Advances in Therapy
Rubens BelfortAna Luisa Höfling-Lima

Abstract

Treatments that offer two medications in a fixed combination have the potential to offer efficacious and safe treatment with advantages such as a regimen that is simpler than administering two separate solutions. This study evaluated the safety and efficacy of fixed-combination versus concomitant moxifloxacin 0.5% and dexamethasone 0.1% ocular solutions for the treatment of bacterial ocular inflammation and infection. The clinical study design was a randomized, double-masked, active-controlled, parallel-group trial of 102 subjects with bacterial blepharitis in which two patients also had bacterial conjunctivitis. All subjects received two bottles of study medication: either a fixed combination of moxifloxacin 0.5%/dexamethasone 0.1% ophthalmic solution and placebo eye drops (fixed-dose group), or moxifloxacin 0.5% ophthalmic solution and dexamethasone 0.1% (concomitant group). One drop of each study medication was instilled bilaterally four times per day for 7 days. Clinical resolution, signs, symptoms, and safety were assessed. Microbiological specimens were collected from the eyelid margin and conjunctivae of each eye from each patient at the time of enrollment and at the exit visit. Clinical resolution occurred similarly in ...Continue Reading

Citations

Oct 7, 2014·The Ocular Surface·Stephen C PflugfelderVictor L Perez
Jan 21, 2016·Ocular Immunology and Inflammation·Timothy L Comstock, Heleen H DeCory
Feb 2, 2017·Ocular Immunology and Inflammation·Matthew F ChersichLuca Cimino
Jul 6, 2019·Cornea·Edward J HollandFrancis S Mah
Apr 4, 2020·Vestnik oftalmologii·T N SafonovaV V Sidorov

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