Safety and Efficacy of Multipoint Pacing in Cardiac Resynchronization Therapy: The MultiPoint Pacing Trial

JACC. Clinical Electrophysiology
Imran NiaziMPP Investigators

Abstract

The MultiPoint Pacing (MPP) trial assessed the safety and efficacy of pacing 2 left ventricular sites with a quadripolar lead in patients with heart failure indicated for a CRT-D device. Cardiac resynchronization therapy nonresponse is a complex problem where stimulation of multiple left ventricular sites may be a solution. Enrolled patients were indicated for a CRT-D system. Bi-ventricular (Bi-V) pacing was activated at implant. Three months later, clinical response was assessed and the patient was randomized (1:1) to receive Bi-V pacing or MPP. Patients were followed for 6 months post-randomization and clinical response was again assessed. The CRT-D system was successfully implanted in 455 of 469 attempted implants (97%). A total of 381 patients were randomized to Bi-V or MPP at 3 months. The primary safety endpoint was met with freedom from system-related complications of 93.2%. The primary efficacy endpoint of the noninferiority comparison of nonresponder rates between the 2 arms was met. Patients randomized to MPP arm and programmed to pace from anatomically distant poles (MPP-AS) responded to therapy at significantly higher rates than MultiPoint pacing-other programmed settings (MPP-Other). Within this group, 87% were res...Continue Reading

Associated Clinical Trials

References

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Citations

Feb 1, 2020·Journal of Cardiovascular Medicine·Francesco SolimeneAntonio D'Onofrio
May 28, 2019·European Cardiology·Christos-Konstantinos AntoniouDimitrios Tousoulis
Jun 29, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Philipp HalbfassThomas Deneke
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Apr 9, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Francesco ZanonFrits W Prinzen
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Oct 9, 2020·Circulation. Arrhythmia and Electrophysiology·Niraj VarmaRaffaele Corbisiero
Nov 29, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bengt HerwegPugazhendhi Vijayaraman
Mar 8, 2021·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Christos-Konstantinos AntoniouCostas Tsioufis
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Aug 19, 2021·Pacing and Clinical Electrophysiology : PACE·Michael N DruckerKimberly A Parks
Aug 12, 2021·Journal of Cardiovascular Electrophysiology·Vishal S MehtaChristopher A Rinaldi

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