Safety and efficacy of N-acetyl-cysteine for prophylaxis of ventilator-associated pneumonia: a randomized, double blind, placebo-controlled clinical trial

Medical Gas Research
Mojtaba SharafkhahSahand Abaszadeh

Abstract

Ventilator-associated-pneumonia (VAP) is characterized by morbidity, mortality, and prolonged length of stay in intensive care unit (ICU). The present study aimed to examine the effect of N-acetyl-cysteine (NAC) in preventing VAP in patients hospitalized in ICU. We performed a prospective, randomized, double-blind, placebo-controlled trial of 60 mechanically ventilated patients at high risk of developing VAP. NAC (600 mg/twice daily) and placebo (twice daily) were administered to NAC group (n = 30) and control group (n = 30), respectively, through the nasogastric tube in addition to routine care. The clinical response was considered as primary (incidence of VAP) and secondary outcomes. Twenty-two (36.6%) patients developed VAP. Patients treated with NAC were significantly less likely to develop clinically confirmed VAP compared with patients treated with placebo (26.6% vs. 46.6%; P = 0.032). Patients treated with NAC had significantly less ICU length of stay (14.36 ± 4.69 days vs. 17.81 ± 6.37 days, P = 0.028) and less hospital stay (19.23 ± 5.54 days vs. 24.61 ± 6.81 days; P = 0.03) than patients treated with placebo. Time to VAP was significantly longer in the NAC group (9.42 ± 1.9 days vs. 6.46 ± 2.53 days; P = 0.002). The i...Continue Reading

References

Sep 18, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·C ConradR Tirouvanziam

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Citations

Jun 12, 2019·Expert Opinion on Investigational Drugs·George J Kontoghiorghes, Christina N Kontoghiorghe
Apr 24, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Valentine Faure BardonYves Ville
Apr 20, 2019·Frontiers in Pharmacology·Xinming XieManxiang Li
Jun 7, 2020·Medical Hypotheses·Francis L Poe, Joshua Corn
Nov 13, 2020·Therapeutics and Clinical Risk Management·Zhongcheng Shi, Carlos A Puyo
Mar 9, 2021·Computational and Structural Biotechnology Journal·Adrián Palacios ChavarríaMaria Elena Soto

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SPSS
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