PMID: 7514070Jan 1, 1994Paper

Safety and efficacy of nebulized lignocaine in patients with cancer and breathlessness

Palliative Medicine
A WilcockA E Tattersfield

Abstract

Although anecdotal reports suggest nebulized lignocaine may help breathlessness in patients with cancer this has not been examined formally. We report a pilot study comparing nebulized lignocaine 100 mg and 200 mg with saline in six patients with cancer who were breathless at rest. Nebulized lignocaine was well tolerated apart from mild bronchoconstriction in two patients after the 200 mg dose and the unpleasant taste; serum concentrations were below levels at which toxicity has been reported. The effort of breathing (measured on a visual analogue scale) did not differ between treatments, whereas the distress of breathing was less after saline than after either dose of lignocaine. These findings do not support the reported benefits of nebulized lignocaine.

Citations

Sep 10, 2008·Current Oncology Reports·Giovanni Elia, Jay Thomas
Apr 10, 1999·Respiratory Medicine·T W Harrison, A E Tattersfield
Aug 5, 1998·Quality in Health Care : QHC·A Melville, A Eastwood
Apr 1, 1997·Thorax·S Ahmedzai, C Davis
Jan 18, 2011·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Shirley ThomasSara Booth
Oct 16, 2007·Pediatric Clinics of North America·Christina K Ullrich, Oscar H Mayer
Aug 13, 2002·Hematology/oncology Clinics of North America·Deborah J Dudgeon
Jul 1, 1997·Palliative Medicine·G Zeppetella
Dec 29, 1998·The American Journal of Hospice & Palliative Care·G Zeppetella
Sep 2, 1997·International Journal of Palliative Nursing·Carol Birks

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