Safety and efficacy of Profermin® to induce remission in ulcerative colitis.

World Journal of Gastroenterology : WJG
Aleksander KragFlemming Bendtsen

Abstract

To test the efficacy and safety of Profermin(®) in inducing remission in patients with active ulcerative colitis (UC). The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index (SCCAI) > 4 and < 12 (median: 7.5), who were treated open-label with Profermin(®) twice daily for 24 wk. Daily SCCAI was reported observer blinded via the Internet. In an intention to treat (ITT) analysis, the mean reduction in SCCAI score was 56.5%. Of the 39 patients, 24 (62%) reached the primary endpoint, which was proportion of patients with ≥ 50% reduction in SCCAI. Our secondary endpoint, the proportion of patients in remission defined as SCCAI ≤ 2.5, was in ITT analysis reached in 18 of the 39 patients (46%). In a repeated-measure regression analysis, the estimated mean reduction in score was 5.0 points (95% CI: 4.1-5.9, P < 0.001) and the estimated mean time taken to obtain half the reduction in score was 28 d (95% CI: 26-30). There were no serious adverse events (AEs) or withdrawals due to AEs. Profermin(®) was generally well tolerated. Profermin(®) is safe and may be effective in inducing remission of active UC.

References

Aug 29, 1998·Journal of Applied Microbiology·S AhrnéG Molin
Oct 15, 1998·Gut·R S WalmsleyR N Allan
Jun 30, 2005·The American Journal of Gastroenterology·Rodrigo BibiloniR Balfour Sartor
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Stig Bengmark, Robert Martindale
Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Norman A GreenbergRemy Meier
May 15, 2007·Lancet·Daniel C Baumgart, Simon R Carding
May 15, 2007·Lancet·Daniel C Baumgart, William J Sandborn
Jan 29, 2008·Physiology & Behavior·Julia J VolmanJogchum Plat
May 13, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A AratariR Caprilli
Apr 18, 2009·Inflammatory Bowel Diseases·Luca PrisciandaroGordon Howarth
May 15, 2009·Alimentary Pharmacology & Therapeutics·T YamamotoA R Saniabadi
Jul 28, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ajit SoodRakesh K Tandon
Sep 4, 2009·Journal of Clinical Gastroenterology·Elisabet LönnermarkIngegerd Adlerberth

❮ Previous
Next ❯

Citations

Oct 11, 2013·Inflammatory Bowel Diseases·Aleksander KragFlemming Bendtsen
May 7, 2015·Expert Opinion on Therapeutic Patents·Luiz C Di StasiAline Witaicenis
Jan 7, 2015·Pharmacology & Therapeutics·Giovanni CammarotaDiego Currò
Aug 10, 2021·Beneficial Microbes·E Arvidsson NordströmN Larsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.