Safety and efficacy of progressive resistance exercise for Charcot-Marie-Tooth disease in children: a randomised, double-blind, sham-controlled trial

The Lancet Child & Adolescent Health
Joshua BurnsFAST Study Group

Abstract

Exercise is potentially therapeutic for neuromuscular disorders, but a risk of harm exists due to overwork weakness. We aimed to assess the safety and efficacy of progressive resistance exercise for foot dorsiflexion weakness in children with Charcot-Marie-Tooth disease. We did this randomised, double-blind, sham-controlled trial across the Sydney Children's Hospitals Network (NSW, Australia). Children aged 6-17 years with Charcot-Marie-Tooth disease were eligible if they had foot dorsiflexion weakness (negative Z score based on age-matched and sex-matched normative reference values). We randomly allocated (1:1) children, with random block sizes of 4, 6, and 8 and stratification by age, to receive 6 months (three times per week on non-consecutive days; 72 sessions in total) of progressive resistance training (from 50% to 70% of the most recent one repetition maximum) or sham training (negligible non-progressed intensity), using an adjustable exercise cuff to exercise the dorsiflexors of each foot. The primary efficacy outcome was the between-group difference in dorsiflexion strength assessed by hand-held dynamometry (expressed as a Z score) from baseline to months 6, 12, and 24. The primary safety outcome was the between-group ...Continue Reading

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Citations

Jan 25, 2019·Developmental Science·Danielle R PerszykSandra R Waxman
Nov 27, 2018·Brain : a Journal of Neurology·Melissa R MandarakasOranee Sanmaneechai
May 13, 2020·Journal of the Peripheral Nervous System : JPNS·Riccardo ZuccarinoJoshua Burns
Aug 9, 2020·Frontiers in Neurology·Fukiko Kitani-MoriiToshiki Mizuno
Mar 10, 2018·Journal of the Peripheral Nervous System : JPNS·Melissa R MandarakasJoshua Burns
Jul 25, 2019·International Journal of Molecular Sciences·Jonathan MorenaJ Chad Hoyle
May 3, 2019·Physiotherapy Theory and Practice·Cyntia Rogean De BaptistaAna Claudia Mattiello-Sverzut
Feb 28, 2018·American Journal of Lifestyle Medicine·Kirsten Legerlotz
Aug 4, 2021·Current Opinion in Neurology·Melissa R MandarakasJoshua Burns

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