Safety and Efficacy of Rocuronium With Sugammadex Reversal Versus Succinylcholine in Outpatient Surgery-A Multicenter, Randomized, Safety Assessor-Blinded Trial

American Journal of Therapeutics
Roy SotoTiffany Woo

Abstract

Complex surgical procedures are increasingly performed in an outpatient setting, with emphasis on rapid recovery and case turnover. In this study, the combination of rocuronium for neuromuscular blockade (NMB) reversed by single-dose sugammadex was compared with succinylcholine followed by spontaneous recovery in outpatient surgery. This multicenter, randomized, safety assessor-blinded study enrolled adults undergoing a short elective outpatient surgical procedure requiring NMB and tracheal intubation. Patients were randomized to NMB with either rocuronium 0.6 mg/kg for tracheal intubation with incremental doses of rocuronium 0.15 mg/kg and subsequent reversal with sugammadex 4.0 mg/kg at 1-2 posttetanic counts or succinylcholine 1.0 mg/kg for intubation with spontaneous recovery. The primary efficacy end point was the time from sugammadex administration to recovery of the train-of-four ratio to 0.9; for succinylcholine, time from administration to recovery of the first twitch (T1) to 90% was assessed. From 167 patients enrolled, 150 received treatment. The all-subjects-treated population comprised 70 patients in the rocuronium-sugammadex group and 80 in the succinylcholine group. Geometric mean (95% confidence interval) time f...Continue Reading

References

Aug 7, 1999·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·D M Fisher
Nov 29, 2002·Anesthesia and Analgesia·Babatunde O OgunnaikeCharles W Whitten
Nov 10, 2006·Current Opinion in Anaesthesiology·Gabriella Bettelli
Jan 2, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas M Hemmerling, Nhien Le
May 22, 2007·Anesthesia and Analgesia·Paul F WhiteUNKNOWN Fast-Track Surgery Study Group
Jul 19, 2008·Anesthesia and Analgesia·Glenn S MurphyJeffery S Vender
Mar 18, 2010·Anesthesiology·Benoît PlaudJean Marty

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Citations

Jun 22, 2016·Drugs·Gillian M Keating
Oct 20, 2020·Drugs & Aging·Joachim HansenJacob Steinmetz
Jul 28, 2021·The Journal of International Medical Research·Haiyan SunRen Liao

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