Safety and efficacy of telbivudine for chronic hepatitis B during the entire pregnancy: Long-term follow-up

Journal of Viral Hepatitis
J ShangH Tang

Abstract

The management of hepatitis B virus (HBV) infection in pregnancy is a unique issue. Telbivudine (LdT) is recommended to block HBV mother-to-child transmission (MTCT) in the third trimester. However, the safety of LdT treatment during the entire pregnancy for the long-term growth of infants is unclear. The aim of this study was to evaluate the efficacy and long-term safety of LdT for the entire pregnancy period. This retrospective cohort study included 40 pregnant women and 43 children from 2011 to 2017. The antiviral effects and maternal abnormalities were evaluated. In addition, adverse events regarding infants at delivery and HBV vaccination outcomes were recorded. The status of physical development in the children during follow-up was also evaluated. Among pregnant women, the rates of HBV DNA flare were 5.00% during pregnancy and 7.50% postpartum, and the HBeAg seroconversion rates were 7.50% during pregnancy and 7.50% postpartum. No severe maternal abnormalities were observed. Regarding the infants, no one was positive for HBsAg, and only one infant was negative for anti-HBs in children over 7 months of age. Furthermore, no birth defects or severe adverse events were observed at delivery, and 97.67% normal height and 93.02%...Continue Reading

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Citations

Feb 26, 2019·Journal of Viral Hepatitis·Anna TurkovaClaire Thorne
Oct 3, 2018·Expert Opinion on Pharmacotherapy·Premashis Kar, Anando Sengupta
Jan 3, 2020·European Journal of Gastroenterology & Hepatology·Xuesong GaoWei Yi
Mar 17, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jin ShangHong Tang

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