Safety and efficacy of teriparatide treatment for severe osteoporosis in patients with Duchenne muscular dystrophy.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
N NasomyontM M Rutter

Abstract

Osteoporosis is a major concern in patients with Duchenne muscular dystrophy. In this novel study of teriparatide treatment in 6 patients with severe osteoporosis, bone health (fractures, vertebral morphometry, and DXA) remained stable, with no adverse events. These findings will help inform future osteoporosis research in this challenging population. Despite standard therapy with vitamin D and bisphosphonates (BP), many patients with Duchenne muscular dystrophy (DMD) continue to sustain fragility fractures due to long-term glucocorticoid treatment and limited mobility. We aimed to evaluate the safety and efficacy of teriparatide for the treatment of severe osteoporosis in adolescent and young adult patients with DMD. We prospectively treated 6 patients with DMD who had severe osteoporosis with teriparatide 20 mcg subcutaneously daily for 1-2 years. Inclusion criteria were long-term glucocorticoid therapy, and severe osteoporosis despite treatment with BP, or intolerance to BP. We examined long bone and vertebral fracture outcomes, including vertebral morphometry measures, bone mineral density and content, bone formation markers, safety indices, and adverse events. The mean age at teriparatide start was 17.9 years (range 13.9-2...Continue Reading

References

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D R CarterR Marcus
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K GenantM C Nevitt
Jan 24, 2002·AJR. American Journal of Roentgenology·Richard C HendersonH Theodore Harcke
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S OrwollG A Gaich
Sep 23, 2003·The New England Journal of Medicine·Joel S FinkelsteinRobert M Neer
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bruce EttingerImre Pavo
May 13, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R N J de NijsJ W J Bijlsma
Jul 2, 2004·Basic & Clinical Pharmacology & Toxicology·Kim T BrixenBente Lomholt Langdahl
Feb 12, 2005·Archives of Physical Medicine and Rehabilitation·Gillian A HawkerW Douglas Biggar
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Joel S FinkelsteinRobert M Neer
Jul 5, 2007·The Journal of Clinical Endocrinology and Metabolism·Paul D MillerRobert Marcus
Nov 16, 2007·The New England Journal of Medicine·Kenneth G SaagRobert Marcus
Dec 26, 2007·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Gabriele ArmbrechtDieter Felsenberg
Apr 26, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Armen H Tashjian, David Goltzman
Mar 27, 2009·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Babette S ZemelRichard C Henderson
Jul 28, 2009·Journal of Bone and Mineral Metabolism·Christina KeelChristian Meier
Feb 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J J StepanI Pavo
Oct 13, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A BlumsohnUNKNOWN EUROFORS Study Group
Mar 1, 2011·Neuromuscular Disorders : NMD·Maria Luisa BianchiBrian Tseng
Feb 3, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M SbrocchiL M Ward
Jul 25, 2012·Neuromuscular Disorders : NMD·A L MayoW D Biggar
Sep 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth B AndrewsDaniel Masica
Nov 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cristiana CiprianiJohn P Bilezikian
Jan 17, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claus-C GlüerPhilippe K Zysset
Mar 25, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Catherine M GordonBabette S Zemel
Feb 17, 2015·Neuromuscular Disorders : NMD·Elke BraatElena Levtchenko
Nov 26, 2015·Muscle & Nerve·Ramesh SrinivasanAnna Sarkozy
Sep 4, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A CatalanoS Messina
Oct 25, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J MaL M Ward
Feb 6, 2018·Lancet Neurology·David J BirnkrantUNKNOWN DMD Care Considerations Working Group
Jul 7, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A GilsenanE Andrews
Sep 29, 2018·The Journal of Clinical Endocrinology and Metabolism·Joseph M KindlerBabette S Zemel
Nov 25, 2018·The Journal of Pediatrics·Karen K WinerGordon B Cutler
Dec 27, 2018·The New England Journal of Medicine·Lenore Buckley, Mary B Humphrey

❮ Previous
Next ❯

Citations

Jan 12, 2021·Frontiers in Psychology·Ryan R KellyAmanda C LaRue
Jul 8, 2021·Journal of Pediatric Orthopedics·Jennifer J BeckBarbara Minkowitz
Sep 16, 2021·Journal of Endocrinological Investigation·Antonino CatalanoSonia Messina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A CatalanoS Messina
BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Stephanie K A BlickSusan J Keam
© 2021 Meta ULC. All rights reserved