Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.

The New England Journal of Medicine
Fernando P PolackC4591001 Clinical Trial Group


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. Safe and effective vaccines are needed urgently. In an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years of age or older in a 1:1 ratio to receive two doses, 21 days apart, of either placebo or the BNT162b2 vaccine candidate (30 μg per dose). BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine that encodes a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein. The primary end points were efficacy of the vaccine against laboratory-confirmed Covid-19 and safety. A total of 43,548 participants underwent randomization, of whom 43,448 received injections: 21,720 with BNT162b2 and 21,728 with placebo. There were 8 cases of Covid-19 with onset at least 7 days after the second dose among participants assigned to receive BNT162b2 and 162 cases among those assigned to placebo; BNT162b2 was 95% effective in preventing Covid-19 (95% credible interval, 90.3 to 97.6). Similar vaccine efficacy (generally 90 to 100%) was observed acro...Continue Reading


Sep 18, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Katalin KarikóDrew Weissman
Aug 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Norbert PardiDrew Weissman
Dec 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin J CowlingMark G Thompson
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber
Oct 21, 2020·Science Translational Medicine·Barton F HaynesAnn Arvin

❮ Previous
Next ❯


Dec 11, 2020·The New England Journal of Medicine·Eric J Rubin, Dan L Longo
Dec 31, 2020·The New England Journal of Medicine·Lindsey R BadenUNKNOWN COVE Study Group
Jan 5, 2021·Annals of Internal Medicine·Ruanne V Barnabas, Anna Wald
Jan 5, 2021·Annals of Internal Medicine·Ashleigh R TuiteJoshua A Salomon
Dec 29, 2020·Advanced Drug Delivery Reviews·Jee Young ChungYoung Jik Kwon
Jan 10, 2021·Infectious Diseases and Therapy·Sabrina Mattoli
Jan 6, 2021·Computational and Structural Biotechnology Journal·Edison OngYongqun He
Jan 13, 2021·Virchows Archiv : an International Journal of Pathology·Ambrogio FassinaLuisa Barzon
Jan 15, 2021·The Lancet. Gastroenterology & Hepatology·Thomas MarjotEleanor Barnes
Jan 10, 2021·Dermatologic Therapy·Anwita SinhaAnchit Raj Singh
Jan 6, 2021·Advanced Drug Delivery Reviews·Jeonghwan KimGaurav Sahay
Jan 3, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Johann SellnerUNKNOWN EAN NeuroCOVID-19 Task Force
Jan 20, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Christian Bogdan
Jan 19, 2021·Annals of Internal Medicine·Mark ConnorsAnthony S Fauci
Jan 21, 2021·Nature Medicine·Jerome H KimJohn D Clemens
Jan 21, 2021·Applied Health Economics and Health Policy·Andrea ArcangeliLucia Ercoli
Jan 16, 2021·The Journal of Infection·Aodhán Seán BreathnachTimothy David Planche
Jan 25, 2021·The Lancet Infectious Diseases·Christina A Rostad, Evan J Anderson
Jan 22, 2021·Expert Opinion on Therapeutic Patents·Ilaria VicentiFrancesco Saladini
Jan 23, 2021·Journal of Biological Rhythms·Shaon SenguptaJane A McKeating
Jan 28, 2021·Israel Journal of Health Policy Research·Martin McKee, Selina Rajan
Jan 21, 2021·Muscle & Nerve·Sasha A ŽivkovićUNKNOWN AANEM Quality and Patient Safety Committee
Jan 28, 2021·Pathogens·Edyta JanikMichal Bijak
Jan 28, 2021·International Journal of Molecular Sciences·Layaly ShkairSvetlana F Khaiboullina
Jan 4, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Aleena BanerjiKimberly G Blumenthal
Jan 28, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Emilio Sánchez-ÁlvarezUNKNOWN en representación de la Junta Directiva de Sociedad Española de Nefrología
Jan 28, 2021·Pharmaceutics·Marina LuchnerAnita Milicic
Jan 27, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Anthony HarndenAndrew Earnshaw
Dec 29, 2020·Lancet·Sophie HarmanClare Wenham
Jan 28, 2021·Vaccines·Ivana KnezevicHye-Na Kang
Jan 31, 2021·Rheumatology International·Tsvetelina Velikova, Tsvetoslav Georgiev
Feb 2, 2021·Emerging Infectious Diseases·Sharon AmitGili Regev-Yochay
Feb 3, 2021·British Journal of Nursing : BJN·Rebecca M Osbourne, Samuel J Clark
Dec 31, 2020·The New England Journal of Medicine·Barton F Haynes
Jan 12, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R J Martinez-PortillaL C Poon
Feb 4, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vikram Bhise, Suhayl Dhib-Jalbut
Jan 11, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michele CarboneEnrico Bucci
Feb 5, 2021·British Journal of Community Nursing·Alison Phillis
Feb 6, 2021·AJR. American Journal of Roentgenology·Christine E EdmondsEmily F Conant

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Danuta M Skowronski, Gaston De Serres
The New England Journal of Medicine
Jean-Noel Vergnes
The New England Journal of Medicine
Judith AbsalonWilliam C Gruber
© 2021 Meta ULC. All rights reserved