Safety and efficacy of the minilaparotomy for myomectomy: a systematic review and meta-analysis of randomized and non-randomized controlled trials

Reproductive Biomedicine Online
Stefano PalombaGiovanni Battista La Sala

Abstract

Myomectomy is the most frequent reproductive surgery to preserve, improve fertility, or both. The present study was designed to assess the safety and efficacy of minilaparotomy for myomectomy through a systematic review of randomized and non-randomized controlled trials with a meta-analysis. All available studies comparing minilaparotomy myomectomy with laparotomy, other minimally invasive surgeries, or both, were included. Available surgical and reproductive data were extrapolated, and a qualitative and quantitative analysis was carried out. Fourteen studies were included in the final analysis for an overall sample of 2151 patients. A total of 1139 patients were treated with minilaparotomy, whereas 239 and 773 patients were treated, respectively, with the laparotomy or laparoscopy. Only two studies comparing minilaparotomy with laparoscopy assessed the reproductive outcomes, and their data synthesis did not demonstrate significant difference between the two surgical techniques. Specific surgical end-points differed significantly between minilaparotomy and laparotomy or laparoscopy, even if those differences were not clinically relevant. In conclusion, current data do not permit a definite conclusion to be drawn. Further studie...Continue Reading

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Citations

Dec 18, 2015·Critical Reviews in Oncology/hematology·Giorgio BoganiFrancesco Raspagliesi
Oct 11, 2015·Journal of Minimally Invasive Gynecology·Vincenzo Dario MandatoGiovanni Battista La Sala
Jul 18, 2015·Reproductive Biomedicine Online·Stefano Palomba, Giovanni Battista La Sala
Jul 18, 2015·Reproductive Biomedicine Online·Tae-Hee KimYeon-Suk Kim
Jun 24, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Fabio GhezziStefano Uccella
Aug 19, 2017·Archives of Gynecology and Obstetrics·Cristina CezarRudy Leon De Wilde
Aug 30, 2018·Obstetrics and Gynecology International·Abhilasha AgarwalGazal Jain

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