Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial

PLoS Neglected Tropical Diseases
Alexandra G RafteryDavid G M Sutton

Abstract

Globally, working equines have a continued and growing socioeconomic role in supporting the livelihoods of between 300-600 million people in low income countries which is rarely recognised at a national or international level. Infectious diseases have significant impact on welfare and productivity in this population and equine trypanosomiasis is a priority disease due to its severity and prevalence. Strategies are required to improve the prevention, diagnosis, management and treatment of trypanosomiasis in equines and more data are required on the efficacy and safety of current trypanocidal drugs. A prospective randomised, open-label non-inferiority trial was performed in The Gambia on horses and donkeys that fulfilled 2/5 clinical inclusion criteria (anaemia, poor body condition, pyrexia, history of abortion, oedema). Following randomised trypanocidal treatment (diminazene diaceturate, melarsomine dihydrochloride or isometamidium chloride), animals were observed for immediate adverse drug reactions and follow-up assessment was performed at 1 and 2 weeks. Blood samples underwent PCR analysis with specific Trypanosoma sp. primers. Treatment efficacy was assessed by measuring changes in clinical parameters, clinicopathological re...Continue Reading

References

Jan 1, 1976·Equine Veterinary Journal·J E Smith, N S Agar
Nov 1, 1992·International Journal for Parasitology·D K MasigaW C Gibson
Jan 1, 1988·Journal of Public Health Dentistry·L CohenE Romberg
Sep 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·L D Kinabo, J A Bogan
Jan 1, 1988·Equine Veterinary Journal·C L Carroll, P J Huntington
Mar 1, 1985·Zentralblatt für Veterinärmedizin. Reihe A·D SchillingerD Röttcher
Aug 1, 1981·Tropical Animal Health and Production·A A Ilemobade, T F Balogun
Sep 1, 1993·Acta Tropica·A S Peregrine, M Mamman
Mar 9, 1996·The Veterinary Record·R A Pearson, M Ouassat
May 23, 1998·Journal of Clinical Microbiology·R F MassungJ G Olson
May 15, 1999·Journal of Clinical Microbiology·J M GubbelsF Jongejan
Oct 6, 2001·Veterinary Parasitology·D FayeS Geerts
Dec 17, 2002·Veterinary Parasitology·D TuntasuvanN Kongkanjana
Apr 6, 2004·International Journal for Parasitology·C A L OuraA Tait
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Duncan J Campbell
Jun 26, 2008·Tropical Animal Health and Production·Hamad Bin RashidAsim Khalid Mahmood
Jun 13, 2009·International Journal for Parasitology·Craig W DuffyAnnette MacLeod
Oct 3, 2009·American Journal of Veterinary Research·Rebecca A CarterRaymond J Geor
Sep 14, 2010·The Veterinary Journal·Joy C Pritchard
Jan 26, 2011·Parasite Immunology·B Namangala
Nov 8, 2013·Tropical Animal Health and Production·Muthusamy RanjithkumarSahadeb Dey
Nov 29, 2014·The Veterinary Record·Andy Stringer
May 31, 2016·Cell Host & Microbe·Sandra TrindadeLuisa M Figueiredo

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Citations

Dec 18, 2019·Transboundary and Emerging Diseases·Robert M CoultousWilliam Weir
Mar 23, 2020·Parasites & Vectors·Alexandra G RafteryDavid G M Sutton

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Methods Mentioned

BETA
PCR
electrophoresis

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