PMID: 1984986Jan 1, 1991

Safety and efficacy of thrombolytic therapy for superior vena cava syndrome

B H GrayW F Ruschhaupt


The experience at the Cleveland Clinic from 1982 to 1990 using thrombolytic therapy for superior vena cava (SVC) syndrome was retrospectively reviewed. Sixteen patients, 11 of whom had indwelling central venous catheters, were treated with either urokinase (n = 11) or streptokinase (n = 5). Either urokinase (4,400 U/kg bolus followed by 4,400 U/kg/h) or streptokinase (250,000 U bolus followed by 100,000 U/h) was used, and venograms were performed before and after. Overall, 56 percent of patients had complete clot lysis and relief of symptoms. Thrombolytic therapy was effective in eight (73 percent) of 11 patients receiving urokinase and one (20 percent) of five patients receiving streptokinase. Of those with a central venous catheter, eight (73 percent) of 11 patients were successfully lysed, whereas only one (20 percent) of five patients was successfully lysed if no catheter was present. If thrombolytic therapy was performed less than or equal to five days of symptom onset, seven (88 percent) of eight patients were successful, if thrombolytic therapy was performed greater than five days after symptom onset, two (25 percent) of eight patients were successful. Symptoms were relieved and the catheter was preserved in patients in ...Continue Reading


Jan 6, 1975·JAMA : the Journal of the American Medical Association·R Goodman
Jan 1, 1989·AJR. American Journal of Roentgenology·P Capek, C Cope
May 1, 1989·Archives of Internal Medicine·F L MeisterS D Sholkoff
Nov 1, 1985·The American Journal of Cardiology·J H MontgomeryS H Prabhu
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·C M WilsonD W Thomas
Nov 1, 1988·Annals of Emergency Medicine·J W Olin, R A Graor
Dec 1, 1988·American Journal of Diseases of Children·M P Griffin, A Casta
Sep 1, 1986·Current Problems in Cancer·A F Nieto, D B Doty
Jan 1, 1987·Gynecologic Oncology·J A MatthewsD J Hall
Jan 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·N L SmithS A Khan
Sep 16, 1974·JAMA : the Journal of the American Medical Association
Nov 30, 1967·The New England Journal of Medicine·D E TowR A Holmes
May 1, 1983·Archives of Internal Medicine·P O KatzB L Powell
Jul 15, 1984·Cancer·M BertrandE Scott
May 27, 1982·The New England Journal of Medicine·G V SharmaA A Sasahara
Dec 1, 1981·American Heart Journal·J L HerreraT H Williams


Sep 7, 2004·Clinical Rheumatology·Ismail HantaAli Kocabas
Mar 7, 2008·Emergency Radiology·Vasiliki KostopoulouChristos A Papadimitriou
Aug 26, 1999·Seminars in Oncology Nursing·I S Haapoja, C Blendowski
Mar 1, 1992·Mayo Clinic Proceedings·P C Spittell, D L Hayes
Jan 8, 2010·Revista portuguesa de pneumologia·Nuno Filipe PiresHenrique Queiroga
Aug 13, 2010·Heart, Lung & Circulation·Alexander LautenFrank M Baer
Jul 29, 2008·Revue de pneumologie clinique·P BernaM Riquet
Jul 30, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Rupesh NigamJoseph L Nates
Nov 28, 2006·The Annals of Thoracic Surgery·Hendrik RugeRuediger Lange
Jun 10, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·M A SheikhTeresa L Carman
Mar 25, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·B H Gray
Sep 18, 2012·Pacing and Clinical Electrophysiology : PACE·Sandeep Sainathan, Shahriyour Andaz
Feb 14, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mert DumantepeAzmi Ozler
Jun 1, 1996·Journal of Pediatric Surgery·B D KenneyA L Bensoussan
Sep 1, 1993·Current Problems in Surgery·P W HumphreyD Silver
Feb 1, 1996·Hematology/oncology Clinics of North America·Deborah J Dudgeon, S Rosenthal
Aug 13, 2002·Hematology/oncology Clinics of North America·Deborah J Dudgeon
Feb 23, 2008·The Annals of Thoracic Surgery·Brian E KogonWendy M Book
Feb 5, 2008·Journal of Vascular Surgery·Adnan Z RizviPeter Gloviczki
May 9, 2012·Diagnostic and Interventional Imaging·A LacoutM El Hajjam
Feb 19, 2013·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Vamsidhar Rachapalli, Louis-Martin Boucher
Sep 10, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·Ezra Steiger
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·P J OstlerM N Gaze
Jan 9, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria Luigia RandiAntonio Girolami
Sep 27, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·M D CarcaoV S Blanchette
Mar 24, 2007·Nature Clinical Practice. Cardiovascular Medicine·Cheng E CheeAbhiram Prasad
Oct 1, 1996·Anaesthesia·S RayJ Filshie
Oct 10, 2007·Hemodialysis International·Hadim AkogluCetin Turgan
Oct 6, 2015·Research in Cardiovascular Medicine·Ziae TotonchiHamidreza Pouraliakbar
Nov 1, 1993·The Journal of Urology·M S LaFave, R M Decter
Jan 21, 2000·Medizinische Klinik·W DempkeH J Schmoll
Oct 27, 2020·VASA. Zeitschrift für Gefässkrankheiten·Peter Franz Klein-WeigelLukas Beyer
Nov 20, 2020·Heart Rhythm : the Official Journal of the Heart Rhythm Society·James GabrielsLaurence M Epstein

Related Concepts

Catheterization, Central Venous
Intravenous Infusion Procedures
Retrospective Studies
Superior Vena Cava Thrombosis
Thrombolytic Therapy

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