Safety and efficacy of tirofiban combined with endovascular treatment in acute ischaemic stroke

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
X PanJ Yang

Abstract

Tirofiban is used off-label in clinical practice for acute ischaemic stroke (AIS). However, it is unknown whether tirofiban increases the bleeding risk or improves the outcome of endovascular treatment (EVT) in AIS. This study evaluated the efficacy and safety of tirofiban in combination with EVT for AIS. Consecutive patients with AIS receiving EVT were included in the prospective stroke registry from 2015 to 2018. The efficacy outcomes were modified Rankin Scale (mRS) score at 3 months and National Institutes of Health Stroke Scale (NIHSS) score at 24 h. The safety outcomes were symptomatic intracerebral hemorrhage (sICH), any in-hospital intracerebral hemorrhage, in-hospital death and 3-month death. Of 211 patients, 82 (38.9%) received tirofiban. A total of 39 (48.1%) with tirofiban and 44 (36.1%) without tirofiban had mRS score 0-2 [adjusted odds ratio (OR), 2.41; 95% confidence interval (CI), 1.11-5.23, P = 0.026]. NIHSS score at 24 h was lower in the tirofiban group (9.5 vs. 12.0, adjusted P = 0.032). Five (6.1%) patients with tirofiban and 16 (12.4%) without tirofiban had sICH (adjusted OR, 0.54; 95% CI, 0.16-1.83, P = 0.32). In-hospital intracerebral hemorrhage occurred in 10 (12.2%) patients with tirofiban and 41 (31.8%...Continue Reading

References

Jun 11, 2005·Stroke; a Journal of Cerebral Circulation·Marta RubieraCarlos A Molina
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Aug 20, 2011·Stroke; a Journal of Cerebral Circulation·Mario SieblerJochen B Fiebach
Mar 7, 2013·Stroke; a Journal of Cerebral Circulation·Lars KellertSibylle Stampfl
Dec 18, 2014·The New England Journal of Medicine·Olvert A BerkhemerUNKNOWN MR CLEAN Investigators
Feb 12, 2015·The New England Journal of Medicine·Bruce C V CampbellUNKNOWN EXTEND-IA Investigators
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Apr 18, 2015·The New England Journal of Medicine·Jeffrey L SaverUNKNOWN SWIFT PRIME Investigators
Apr 18, 2015·The New England Journal of Medicine·Tudor G JovinUNKNOWN REVASCAT Trial Investigators
Jul 19, 2015·Vascular Pharmacology·Shawn KingCassidy Harmon
Jan 8, 2017·Stroke; a Journal of Cerebral Circulation·Sònia AbilleiraUNKNOWN Catalan Stroke Code and Reperfusion Consortium
Apr 5, 2017·Stroke; a Journal of Cerebral Circulation·Yonggang HaoUNKNOWN ACTUAL Investigators (Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke Registry)
Jul 28, 2017·Stroke; a Journal of Cerebral Circulation·Eva A MistryMatthew R Fusco
Nov 18, 2017·Journal of Neurointerventional Surgery·Romain BourcierHubert Desal

❮ Previous
Next ❯

Citations

Jan 5, 2020·European Journal of Clinical Pharmacology·Jinhong GongGuangjun Liu
Sep 17, 2020·Stroke; a Journal of Cerebral Circulation·Jianhong YangUNKNOWN INSPIRE Study Group†
Apr 2, 2021·Stroke; a Journal of Cerebral Circulation·Byung Hyun BaekMan Seok Park
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yu GuoMingfei Yang
Jul 25, 2021·AJNR. American Journal of Neuroradiology·S H JangJ-H Hong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.