Safety and efficacy of topical diclofenac sodium 1% gel in knee osteoarthritis: a randomized controlled trial

The Physician and Sportsmedicine
Herbert S BarafRoy D Altman

Abstract

Topical nonsteroidal anti-inflammatory drugs (NSAIDs) may provide an alternative to oral NSAIDs to relieve pain from osteoarthritis (OA), reducing systemic exposure. This 12-week, randomized, double-blind, parallel-group, multicenter trial examined the efficacy and safety of topical diclofenac sodium 1% gel (DSG) for symptomatic knee OA. Eligible patients were aged >/= 35 years with symptomatic Kellgren-Lawrence grade (KLG) 1 to 3 OA in 1 or both knees for >/= 6 months. Patients meeting entry criteria applied DSG 4 g or vehicle 4 times daily to the symptomatic knee(s). Primary endpoints were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical function subscales and global rating of benefit at week 12. Pain on movement at week 4 was an additional primary endpoint for European regulatory purposes. Secondary endpoints included primary outcomes at weeks 1, 4, and 8; WOMAC stiffness subscale; spontaneous pain; global rating of disease; and global evaluation of treatment. Subanalyses were performed according to KLG, the number of knees treated, and age. Four hundred twenty patients were randomly assigned to DSG (n = 208) or vehicle (n = 212). At week 12, DSG provided significantly greater reductio...Continue Reading

References

Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Dec 3, 2003·Annals of the Rheumatic Diseases·K M JordanUNKNOWN Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT
Mar 5, 2004·American Journal of Therapeutics·Robert L Barkin, Asokumar Buvanendran
Aug 20, 2004·BMC Musculoskeletal Disorders·Lorna MasonHenry J McQuay
Feb 24, 2006·The American Journal of Medicine·Gurkirpal SinghUNKNOWN SUCCESS-I Investigators
Jul 1, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Stephen P MotskoJason Worchel
Jan 27, 2009·Journal of Clinical Gastroenterology·Linda J ChunJonathan R Hiatt
Oct 21, 2009·Journal of Clinical Pharmacology·Jean-Luc KienzlerFabrice Nollevaux
Nov 26, 2009·Seminars in Arthritis and Rheumatism·H Richard BarthelRoy D Altman
Nov 27, 2009·Postgraduate Medicine·Rajitkanok Amy Puenpatom, Timothy W Victor
Mar 17, 2010·Journal of Sport Rehabilitation·Giampietro L VairoWilliam E Buckley

❮ Previous
Next ❯

Citations

Jul 15, 2011·Clinical Interventions in Aging·Sanford H Roth
Aug 4, 2011·Journal of Pain Research·Sanford H Roth, Philip Fuller
Jul 7, 2012·Therapeutics and Clinical Risk Management·Howard S SmithBenjamin R Smith
Jul 21, 2011·Drugs·Roy D Altman, H Richard Barthel
Jan 1, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mary Lynn McPherson, Nina M Cimino
Jan 24, 2012·The American Journal of Geriatric Pharmacotherapy·Herbert S B BarafMatthew S Wieman
Mar 28, 2012·Journal of Pain & Palliative Care Pharmacotherapy·Christopher M Herndon
Jul 16, 2014·Pain·Jörn LötschAlfred Ultsch
Jul 22, 2008·Rheumatic Diseases Clinics of North America·R Andrew MooreHenry J McQuay
Mar 3, 2011·The Journal of Rheumatology·Roy D Altman
Sep 10, 2011·Postgraduate Medicine·Robert L BarkinAllan Gordon
Oct 28, 2011·The Physician and Sportsmedicine·Roy D Altman, Peter J Fowler
Apr 23, 2016·The Cochrane Database of Systematic Reviews·Sheena DerryR Andrew Moore
Nov 19, 2010·Postgraduate Medicine·H Richard Barthel, Robert A Axford-Gatley
Nov 23, 2011·Postgraduate Medicine·Matthew J Bair, Tamara R Sanderson
Oct 28, 2011·The Physician and Sportsmedicine·John H PenistonLawrence K Alwine
Nov 19, 2010·Postgraduate Medicine·Roy D Altman, Howard S Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.