Safety and efficacy study of lung cancer stem cell vaccine

Immunologic Research
Mao LinQiao Li

Abstract

In this trial, lung cancer stem cells (CSCs) were separated and cultured to produce a vaccine; its safety and efficacy were prospectively evaluated in low-, medium-, and high-dose groups. Between February and September 2014, we enrolled 90 patients who met the enrollment criteria and assigned them to three groups (n = 30). Throughout the trial, injection site reaction was the most common reaction (63 %), and fever was least common (16 %); however, there was no difference among the three groups. When the immune responses pre- and post-vaccination were compared, we found that the CSC-nonspecific and CSC-specific responses were both significantly enhanced in the medium- and high-dose groups. This study is the first clinical trial of a lung CSC vaccine and preliminarily proves its safety and efficacy.

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Citations

Dec 15, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mei Guo, Jun Dou
Nov 10, 2018·Anti-cancer Agents in Medicinal Chemistry·Hanjiao QinZhuo Zhang
Oct 9, 2020·The International Journal of Biochemistry & Cell Biology·Elena QuaglinoLaura Conti

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