Safety and feasibility of dobutamine-atropine stress testing in hypertensive patients

Hypertension
A ElhendyP M Fioretti

Abstract

Dobutamine stress testing is increasingly used for the diagnosis and functional evaluation of coronary artery disease. The aim of this study was to assess the hemodynamic profile, safety, and feasibility of dobutamine stress testing in hypertensive patients. Dobutamine (up to 40 micrograms/kg per minute)-atropine (up to 1 mg) stress echocardiography was performed for the detection of myocardial ischemia in 1164 patients with limited exercise capacity (age, 60 +/- 12 years; 761 men); 446 patients were known to have hypertension. The test was considered feasible when 85% of the maximal heart rate and/or an ischemic end point (new or worsened wall motion abnormalities, ST segment depression, or angina) was achieved. No myocardial infarction or death occurred during the test. Dobutamine induced a significant increase of heart rate in patients with and without hypertension (59 +/- 25 and 63 +/- 23 beats per minute, respectively). Peak rate pressure product was similar in patients with and without hypertension (18,566 +/- 4584 and 18,230 +/- 4508). Hypotension (systolic pressure drop > 40 mm Hg) during the test was more frequent in hypertensive patients (7% versus 4% in normotensive, P < .05). Independent predictors of hypotension we...Continue Reading

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Citations

Oct 31, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A ElhendyJ R Roelandt
Jul 20, 2002·Journal of Hypertension·Giovanni de Simone, Maurizio Galderisi
Jul 20, 2002·Journal of Hypertension·Lauro CortigianiEugenio Nannini
Dec 2, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ilias KarabinosDemosthenes Katritsis
Aug 19, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·B A KonkleB Ewenstein
Oct 2, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ana Clara Tude RodriguesWilson Mathias
Jun 10, 1998·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A ElhendyJ R Roelandt
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·F LattanziA Varga

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