Safety and immediate effect of noninvasive transcranial pulsed current stimulation on gait and balance in Parkinson disease

Neurorehabilitation and Neural Repair
G AlonMark W Rogers

Abstract

Noninvasive electrical stimulation of the brain (ESB) is being investigated as a valued intervention to enhance motor performance. To ascertain the safety and ability of transcranial pulsed current stimulation (tPCS) to modulate variables of protective stepping and gait of individuals with Parkinson's disease. Ten patients participated in a pilot study. During the first session, a tPCS delivered current for 20 minutes via a positive electrode placed over the primary motor area (M1). In week 2, participants walked for 20 minutes on a treadmill. In week 3, tPCS and treadmill for 20 minutes were combined. Pre-testing and post-testing of gait and protective stepping were administered, comparing post-intervention (tPCS alone, treadmill alone, tPCS + treadmill) with pre-intervention data. The 3 interventions were compared by calculating the difference between post-intervention and pre-intervention data. A significance level of P < .05 was adopted. Stride length increased from 102.1 ± 24.4 to 111.2 ± 22.1 cm, and gait velocity increased from 0.90 ± 0.23 to 0.985 ± 0.19 m/s after tPCS. Treadmill or treadmill + tPCS did not result in changes in the studied gait parameters. The tPCS session increased gait velocity and stride length signi...Continue Reading

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Citations

Feb 27, 2014·Biotechnology & Genetic Engineering Reviews·Yong-Ak SongSamuel J Lin
Apr 2, 2014·Neuroscience Letters·D KaskiR O Dominguez
Mar 5, 2016·Frontiers in Neuroscience·Mufti Mahmud, Stefano Vassanelli
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Dec 19, 2018·Frontiers in Neuroscience·Farrokh MansouriJonathan Downar
Jun 26, 2020·Frontiers in Neuroscience·Jacky GangulyMandar Jog
Dec 16, 2020·Neural Regeneration Research·Wen-Jing WangChun-Lei Shan

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