Safety and immunogenicity of a two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): a randomised, observer-blind, participant-blind, placebo-controlled, phase 2 trial.

The Lancet Infectious Diseases
Andrew J PollardEBOVAC2 EBL2001 study group

Abstract

To address the unmet medical need for an effective prophylactic vaccine against Ebola virus we assessed the safety and immunogenicity of three different two-dose heterologous vaccination regimens with a replication-deficient adenovirus type 26 vector-based vaccine (Ad26.ZEBOV), expressing Zaire Ebola virus glycoprotein, and a non-replicating, recombinant, modified vaccinia Ankara (MVA) vector-based vaccine, encoding glycoproteins from Zaire Ebola virus, Sudan virus, and Marburg virus, and nucleoprotein from the Tai Forest virus. This randomised, observer-blind, placebo-controlled, phase 2 trial was done at seven hospitals in France and two research centres in the UK. Healthy adults (aged 18-65 years) with no history of Ebola vaccination were enrolled into four cohorts. Participants in cohorts I-III were randomly assigned (1:1:1) using computer-generated randomisation codes into three parallel groups (randomisation for cohorts II and III was stratified by country and age), in which participants were to receive an intramuscular injection of Ad26.ZEBOV on day 1, followed by intramuscular injection of MVA-BN-Filo at either 28 days (28-day interval group), 56 days (56-day interval group), or 84 days (84-day interval group) after the...Continue Reading

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Citations

Jan 31, 2021·NPJ Vaccines·Helen R WagstaffeMartin R Goodier
Mar 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ruikang LiuBernard Moss
Apr 14, 2021·Nature Medicine·Jean-Louis ExclerJerome H Kim
May 4, 2021·Frontiers in Veterinary Science·Virginia AidaConstantinos S Kyriakis
Apr 7, 2021·JCI Insight·Jonathan L GolobAnna S Lok
May 1, 2021·Environmental Microbiology·Harald Brüssow
Jul 16, 2021·Science Translational Medicine·Michelle MeyerAlexander Bukreyev
Jul 27, 2021·Stroke; a Journal of Cerebral Circulation·James E SieglerThanh N Nguyen
Jul 31, 2021·Current Opinion in Pharmacology·Ashish Ranjan SharmaSang-Soo Lee
Jul 28, 2021·Nature Medicine·Tina SchmidtMartina Sester
Aug 6, 2021·Journal of Internal Medicine·Xaquin Castro DopicoGunilla B Karlsson Hedestam
Aug 13, 2021·Nature Nanotechnology·Thomas KisbyKostas Kostarelos
Sep 1, 2021·Curēus·Amr SalehRahul Kashyap
Oct 7, 2021·Der Internist·Anahita Fathi, Sibylle C Mellinghoff
Oct 23, 2021·Experimental and Therapeutic Medicine·Gabriella MarfeArvind Kumar Shukla
Nov 6, 2021·Electrophoresis·Lars GeurinkCari Sänger-van de Griend

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