Safety and immunogenicity of an investigational quadrivalent meningococcal CRM(197) conjugate vaccine, MenACWY-CRM, compared with licensed vaccines in adults in Latin America

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
D StamboulianP M Dull

Abstract

This study compared the investigational quadrivalent meningococcal CRM₁₉₇ conjugate vaccine, MenACWY-CRM, with licensed quadrivalent polysaccharide (MPSV4) and conjugate (MenACWY-D) meningococcal vaccines. In this phase III multicenter study, 2505 adults (aged 19-55 years) were randomized to receive either MenACWY-CRM or MenACWY-D, and 326 adults (aged 56-65 years) were randomized to receive either MenACWY-CRM or MPSV4. Sera obtained pre-vaccination and at 1-month post-vaccination were tested for serogroup-specific serum bactericidal activity using human complement (hSBA) for immunogenicity non-inferiority and superiority analyses. The vaccines in all groups were well tolerated. In the 19-55 years age group, post-vaccination geometric mean titers (GMTs) were consistently higher for MenACWY-CRM than for MenACWY-D for all four serogroups. MenACWY-CRM was non-inferior to MenACWY-D for all serogroups, and superior for serogroup Y. In the 56-65 years age group, post-vaccination GMTs were 1.2- to 5.4-fold higher for MenACWY-CRM than for MPSV4 for the four serogroups. MenACWY-CRM is well tolerated and immunogenic in adults aged 19-65 years, with at least non-inferior immunogenicity compared with the currently licensed meningococcal va...Continue Reading

References

Jan 1, 1988·The Journal of Infection·M K Hassan-KingB M Greenwood
Nov 11, 1988·JAMA : the Journal of the American Medical Association·P S MooreC V Broome
Apr 1, 1985·Statistics in Medicine·O Miettinen, M Nurminen
Nov 24, 1999·The Journal of Infectious Diseases·N E RosensteinA L Reingold
Feb 15, 2001·JAMA : the Journal of the American Medical Association·P De WalsT Niyonsenga
Aug 10, 2001·JAMA : the Journal of the American Medical Association·L H HarrisonJ C Roche
Feb 15, 2003·BMJ : British Medical Journal·Mary E RamsayElizabeth Miller
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Dominic F KellyE Richard Moxon
Jan 19, 2006·Clinical Microbiology Reviews·Lee H Harrison
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pascal BoisierSuzanne Chanteau
Jun 8, 2007·Emerging Infectious Diseases·Nicolas NathanDominique A Caugant
Jul 3, 2007·Lancet·David S StephensPetter Brandtzaeg
Sep 13, 2007·The Pediatric Infectious Disease Journal·Dan M Granoff, Andrew J Pollard
May 30, 2008·Emerging Infectious Diseases·Clara Inés AgudeloMaría Victoria Ovalle
Sep 4, 2008·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Jean-Marc GabastouUNKNOWN Grupo de Laboratorio de SIREVA II
May 30, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa A JacksonUNKNOWN V59P13 Study Group

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Citations

Apr 15, 2011·Médecine et maladies infectieuses·M AubertUNKNOWN Groupe Avancées Vaccinales France
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Natalia IlyinaAshwani Kumar Arora
May 10, 2016·Expert Review of Vaccines·Giulia PicciniEmanuele Montomoli
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Michael E Pichichero
Sep 20, 2019·Journal of Aging Research·Gabriela Trzewikoswki de Lima, Elizabeth De Gaspari
Jan 9, 2021·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Sarah A MbaeyiJessica R MacNeil
Oct 14, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ziad A MemishRay Borrow
Oct 16, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hoan Jong LeeTatjana Odrljin

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