Safety and immunogenicity of recombinant human immunodeficiency virus-like particles in rodents and rhesus macaques

Intervirology
Ralf WagnerJ L Heeney

Abstract

Data from long-term non-progressing human immunodeficiency virus (HIV)-infected individuals and populations at high risk suggest that an early cytolytic T cell response rather than the humoral immune response might be involved in controlling disease progression. These observations may be used as a guide to the type of response that a vaccine should induce. To clarify the role of different arms of the immune system in conferring protection, the candidate vaccine should allow a regulated, selective induction of different immune responses. Based on a better understanding of the molecular mechanisms regulating the morphogenesis of HIV, we developed an autologous, non-replicating and safe antigen delivery system. This system takes advantage of molecular characteristics of the HIV group-specific antigens (gag) to self-assemble to highly immunogenic virus-like particles (VLP). The immunogenicity of the gag-derived VLP was expanded either by replacing defined domains by selected HIV-1 cytotoxic T lymphocyte (CTL) epitopes (type 1 VLP) or by stable anchoring derivatives of the HIV-1 envelope protein on the surface of the VLP (type 2 VLP). In complete absence of adjuvants, type 1 and type 2 VLP stimulated CD8+ CTL in BALB/c mice, which s...Continue Reading

Citations

Oct 7, 2010·Expert Review of Vaccines·António RoldãoPaula M Alves
Jan 28, 2006·AIDS Research and Human Retroviruses·Kelly R Young, Ted M Ross
Aug 30, 2008·The Journal of General Virology·Gerald K ChegeAnna-Lise Williamson
Jul 9, 1999·Reviews in Medical Virology·C Porta, G P Lomonossoff
Oct 22, 2003·Der Internist·J Wild, R Wagner
Oct 7, 2009·Expert Review of Vaccines·Franco Maria BuonaguroLuigi Buonaguro

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