Safety and initial efficacy of radiation segmentectomy for the treatment of hepatic metastases​

Journal of Gastrointestinal Oncology
Craig MeiersBeau Toskich

Abstract

Hepatic metastatectomy and ablation are associated with prolonged survival, but not all lesions are anatomically amenable to these therapies. We evaluated safety and initial efficacy of segmental ablative transarterial radioembolization, or radiation segmentectomy (RS), as a treatment for hepatic metastases. A single institution retrospective analysis was performed of patients with hepatic metastases, determined unamenable to resection by a multidisciplinary tumor board, treated with RS from 2015-2017. Safety parameters evaluated were pre and post procedure liver chemistry, MELD score, ALBI grade, platelet count, and adverse events using both Common Terminology Criteria for Adverse Events (CTCAE) v 4.0 and Clavien Dindo (CD) classifications. Initial efficacy was evaluated using RECIST, mRECIST, and PERCIST criteria. Ten patients underwent between 1-3 RS treatments. There was no clinical treatment toxicity or significant post-treatment change in liver chemistry, MELD, or ALBI score. One patient had a CTCAE Grade 1/CD Grade 1 adverse event. All patients showed partial or complete imaging response at initial assessment (1-3 months). Seven patients demonstrated disease control at a mean of 7.1 months post treatment. Three patients ...Continue Reading

Citations

Jul 18, 2019·Cardiovascular and Interventional Radiology·Nancy KemenyConstantinos T Sofocleous
Sep 19, 2020·Journal of Surgical Oncology·Siddharth A PadiaDavid S Shin
Dec 18, 2020·Seminars in Interventional Radiology·Cathal O'LearySusan Shamimi-Noori
Dec 18, 2020·Seminars in Interventional Radiology·Guy E Johnson, Siddharth A Padia
Feb 20, 2021·Abdominal Radiology·I KurilovaC T Sofocleous
Aug 30, 2021·Revista Española De Medicina Nuclear E Imagen Molecular·E M Triviño-IbáñezA Rodríguez-Fernández

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