Safety and Localization of Mesenchymal Stromal Cells Derived from Human Adipose Tissue-Associated Hyaluronic Acid: A Preclinical Study

Stem Cells International
Janaína José Dos Santos MachadoRegina Coeli Goldenberg

Abstract

Millions of plastic surgeries are performed worldwide every year with the objective of correcting lipodystrophies stemming from lesions, tumor resections, birth defects, and AIDS-associated antiretroviral therapy. Besides that, a large number of clinical research have assessed the outcome of procedures that rely on combinations of dermal fillers and autologous cells. However, little is known about the safety of these combinations and the localization of the injected cells. The aim of this study was to test the toxicity of a solution containing 1% hyaluronic acid (HA) and adipose-derived stromal cells (ASCs) from the human adipose tissue and to assess the localization of the injected cells, with and without HA, labeled with technetium-99m. Rats received subcutaneous and intraperitoneal injections of a solution containing 1% HA/adipose-derived stromal cells isolated from the human fat tissue. The animals were then observed for up to forty-two days. The solution tested in this study did not result in systemic, biochemical, or anatomic alterations that could represent toxicity symptoms. The association of HA and ASCs labeled with technetium-99m remained at the site of the injection within a period of twenty-four hours, as demonstra...Continue Reading

References

Jan 1, 1978·Physiological Reviews·W D Comper, T C Laurent
Dec 29, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·F DurantiM L Rosati
Jun 26, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Paul M FriedmanRoy G Geronemus
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Nov 19, 2003·Clinics in Plastic Surgery·Marc H Hedrick, Eric J Daniels
Mar 18, 2006·Arquivos brasileiros de endocrinologia e metabologia·Angélica M M ValenteAntonio R Chacra
Nov 7, 2006·Clinics in Plastic Surgery·Leslie Baumann
May 13, 2008·Clinics in Dermatology·Marina Romagnoli, Magda Belmontesi
Jun 3, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kotaro YoshimuraKiyonori Harii
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joel L Cohen
Aug 16, 2008·Aesthetic Plastic Surgery·V Cervelli, P Gentile
Aug 23, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Henry H RowshanPeter Skidmore
Sep 17, 2008·Dermatologic Clinics·Pedro HerranzMatias Mayor
Jan 24, 2009·Biochimica Et Biophysica Acta·Abhimanyu Garg, Anil K Agarwal
Jun 6, 2009·Current Opinion in Lipidology·Vinaya Simha, Abhimanyu Garg
Jul 10, 2009·Aesthetic Plastic Surgery·Valerio CervelliPietro Gentile
Nov 17, 2009·The Breast Journal·Kotaro YoshimuraKiyonori Harii
Dec 21, 2010·Journal of the American Academy of Dermatology·Luis RequenaLorenzo Cerroni
Mar 23, 2011·Advances in Skin & Wound Care·Valerio CervelliBarbara De Angelis
Jul 1, 2011·Aesthetic Plastic Surgery·Marco PignattiGiorgio De Santis
May 29, 2012·Plastic and Reconstructive Surgery·Phanette GirRod J Rohrich
Mar 26, 2013·Head and Neck Pathology·Roy EversoleJohn Campbell
Dec 24, 2013·Clinical, Cosmetic and Investigational Dermatology·David Funt, Tatjana Pavicic
Jul 2, 2014·BioMed Research International·Paulo Henrique Rosado-de-CastroLea Mirian Barbosa da Fonseca
Jul 6, 2014·Annals of Maxillofacial Surgery·S M Balaji
Aug 30, 2014·Aesthetic Surgery Journal·Maciej NowackiRafał Czajkowski
Sep 19, 2014·Cell Biology International·Hojjat Naderi-MeshkinNaghmeh Ahmadiankia
Apr 15, 2015·Dermatology : International Journal for Clinical and Investigative Dermatology·Minerva BeckerUNKNOWN LIPO and Metabolism Group
Jun 5, 2015·Stem Cell Research & Therapy·Grazielle Dias SuhettBianca Gutfilen
Aug 19, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Charlotte LequeuxCéline Auxenfans
Dec 29, 2015·Journal of Visualized Experiments : JoVE·Jayesh DudhiaRoger K W Smith
Feb 18, 2016·Stem Cells International·Mayra Lorena MoreiraPaulo Henrique Rosado-de-Castro
Nov 1, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Anna BajekTomasz Drewa
Nov 25, 2016·Bulletin of Experimental Biology and Medicine·D N SilachevG T Sukhikh
Jan 25, 2017·International Journal of Molecular Sciences·Meenakshi GaurVictoria V Lunyak

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Citations

Feb 26, 2021·Stem Cells International·Francesco De FrancescoAli Mobasheri

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Methods Mentioned

BETA
FCS
sedation

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