Safety and long-term efficacy of sirolimus eluting stent in ST-elevation acute myocardial infarction: the REAL (Registro REgionale AngiopLastiche Emilia-Romagna) registry

Cardiovascular Drugs and Therapy
Gianfranco PercocoReal Investigators

Abstract

Limited data are available for sirolimus eluting stent (SES) implantation in patients with ST-segment elevation myocardial infarction (STEMI). To confirm the safety and effectiveness of SES in patients with STEMI in a real-world scenario (multicentric registry). From July 2002 to June 2004, clinical and angiographic data of 1617 patients with STEMI treated with primary percutaneous coronary intervention (PCI) have been collected. Patients were prospectively followed for the occurrence of major adverse cardiac events (MACE): death, reinfarction and target vessel revascularization (TVR). Overall, 205 patients received SES (12.5%, SES group) and 1412 received bare metal stent (87.5%, BMS group) in the infarct related artery. Compared with the BMS group, SES patients were younger, had more often diabetes mellitus, anterior localization and less cardiogenic shock at admission. The angiographic characteristics in the SES group showed longer lesions and smaller diameter of vessels. After a median follow-up of 396 days, there was no significant difference in the rate of stent thrombosis (1% in the SES group vs 1.5% in the BMS group, p=ns). The incidence of MACE was significantly lower in the SES group compared to BMS group (HR 0.62 [95...Continue Reading

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Citations

Mar 12, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Alban DibraAdnan Kastrati
Sep 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Santiago Jimenez-ValeroLuis Rodriguez Padial
Dec 15, 2007·Cardiovascular Drug Reviews·Ajay J Kirtane, Martin B Leon
Apr 17, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michele RomanoRoberto Zanini
May 2, 2009·Journal of the American College of Cardiology·Somjot S BrarGeorge Dangas
Dec 4, 2008·Critical Pathways in Cardiology·Yasmin S HamiraniRaymond D Bahr

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