Safety and Long-term Scleral Biomechanical Stability of Rhesus Eyes after Scleral Cross-linking by Blue Light.

Current Eye Research
Yu LiNingli Wang

Abstract

Purpose: To assess the safety and long-term scleral biomechanical stability of rhesus eyes after blue light scleral CXL by investigating the biomechanical and microstructural changes.Methods: Seven rhesus monkeys (14 eyes) were observed in this study. All right eyes received blue light scleral CXL at the superior temporal equatorial sclera, and the left eyes served as controls. Biological ocular parameters were followed up to 1 year after scleral CXL. Stress-strain measurements of three rhesus sclera were measured, three rhesus retinas were examined histologically by H&E and TUNEL staining. And the microstructure of both the sclera and retina were observed by transmission electron microscopy at 1 year.Results: As for the retinal thickness, choroidal thickness, flow density of retinal superficial vascular networks and flash electroretinography (f-ERG) results, no significant differences were observed between the paired eyes at 1 year (P >.05). At the same time, the scleral collagen fibril distribution was much tighter, and the scleral biomechanical properties were significantly increased in the experimental eyes. However, apoptotic cells and retinal ultrastructural changes could still be found in the retina of the experimental e...Continue Reading

References

Apr 1, 1979·Photochemistry and Photobiology·W T HamA M Clarke
Jan 1, 1990·Vision Research·D van Norren, P Schellekens
Sep 1, 1985·American Journal of Optometry and Physiological Optics·R S Harwerth, E L Smith
Mar 29, 2003·Journal of Biomechanical Engineering·J Crawford DownsRichard T Hart
May 10, 2003·Documenta Ophthalmologica. Advances in Ophthalmology·Bo Lei
Jul 11, 2003·Progress in Retinal and Eye Research·Neville A McBrien, Alex Gentle
Nov 28, 1959·Nature·C D BRIDGES
Mar 31, 2004·Journal of Cataract and Refractive Surgery·Gregor Wollensak, Eberhard Spoerl
Dec 22, 2004·Progress in Retinal and Eye Research·Andreas WenzelCharlotte E Remé
Apr 20, 2005·Japanese Journal of Ophthalmology·Kengo HayashiManabu Mochizuki
Jul 21, 2005·Acta Ophthalmologica Scandinavica·Gregor WollensakGisela Stoltenburg
Sep 10, 2010·Progress in Retinal and Eye Research·Barry B LeeUlrike Grünert
Jun 23, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Miao ZhangMengmeng Wang
Jul 26, 2015·Experimental Eye Research·Hans Peter IseliMike Francke
Nov 26, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hans Peter IseliMike Francke
Jan 7, 2016·Retina·Ling ShenJost B Jonas
Jan 9, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gyu Hyun KimIn-Beom Kim
Jul 25, 2017·American Journal of Ophthalmology·Alessandro MarcheseGiuseppe Querques
Aug 5, 2017·Biological & Pharmaceutical Bulletin·Maho NakamuraHideaki Hara
Jun 18, 2018·Experimental Eye Research·Justyna Widomska, Witold K Subczynski
Jan 2, 2019·Journal of Prosthodontic Research·Rafael Rocha PachecoMarcelo Giannini
May 9, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yu LiFengju Zhang
May 31, 2019·Translational Vision Science & Technology·Xin LiuYanlong Bi
Jun 19, 2019·Investigative Ophthalmology & Visual Science·Sheldon J J KwokSeok-Hyun Yun

❮ Previous
Next ❯

Citations

Jul 31, 2021·Translational Vision Science & Technology·Brecken J BlackburnWilliam J Dupps

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.