Safety and outcomes of resection of butterfly glioblastoma

Neurosurgical Focus
Fara DayaniManish K Aghi

Abstract

OBJECTIVE Butterfly glioblastoma (bGBM) is a rare type of GBM, characterized by a butterfly pattern on MRI studies because of its bihemispheric involvement and invasion of the corpus callosum (CC). There is a profound gap in the knowledge regarding the optimal treatment approach as well as the safety and survival benefits of resection in treating this aggressive brain tumor. In this retrospective study, authors add to our understanding of these tumors by identifying the clinical characteristics and outcomes of patients with bGBM. METHODS An institutional database was reviewed for GBM cases treated in the period from 2004 to 2014. Records were reviewed to identify adult patients with bGBM. Cases of GBM with invasion of the CC without involvement of the contralateral hemisphere and bilateral GBMs without involvement of the CC were excluded from the study. Patient and tumor characteristics were gleaned from the medical records, and volumetric analysis was performed using T1-weighted MRI studies. RESULTS From among 1746 cases of GBM, 39 cases of bGBM were identified. Patients had a mean age of 57.8 years at diagnosis. Headache and confusion were the most common presenting symptoms (48.7% and 33.3%, respectively). The median overall...Continue Reading

References

Apr 1, 1997·International Journal of Radiation Oncology, Biology, Physics·K J SteltzerM S Berger
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 6, 2005·Journal of Neurosurgery·Andrew T ParsaSusan M Chang
Dec 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C BalañaR Rosell
Mar 19, 2009·Journal of Cancer Research and Therapeutics·Amit Agrawal
Mar 23, 2011·Journal of Neurosurgery·Nader SanaiMitchel S Berger
Jul 19, 2012·Journal of Neuro-oncology·Kristine DziurzynskiNicholas Levine
Sep 7, 2014·Journal of Neuro-oncology·Kaisorn L ChaichanaAlfredo Quinones-Hinojosa
Dec 4, 2014·Current Neurology and Neuroscience Reports·Joao Paulo AlmeidaAlfredo Quinones-Hinojosa
Nov 23, 2017·World Neurosurgery·Michael Opoku-DarkoJohn J P Kelly
Dec 21, 2017·Brain Sciences·Montserrat Lara-VelazquezAlfredo Quinones-Hinojosa
Jan 18, 2018·The New England Journal of Medicine·Juveria Siddiqui, Anant S Krishnan

❮ Previous
Next ❯

Citations

Oct 8, 2020·Scientific Reports·Marie-Therese ForsterVolker Seifert
Oct 24, 2020·Acta neurochirurgica·Pamela FrancoOliver Schnell
Jul 10, 2021·Journal of Neurosurgery·Domenique M J MüllerPhilip C De Witt Hamer
Jan 16, 2022·Journal of Neuro-oncology·Nicholas B DadarioCharles Teo

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

Brainlab Smart Brush
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.