Safety and palliative efficacy of single-dose 8-Gy reirradiation for painful local failure in patients with stage IV non-small cell lung cancer previously treated with radical chemoradiation therapy

International Journal of Radiation Oncology, Biology, Physics
Erkan TopkanUgur Selek

Abstract

To investigate the safety and efficacy of single-dose 8-Gy palliative chest reirradiation (CRI) in metastatic non-small cell lung cancer (M-NSCLC) patients with painful thoracic failures (TF) within the previous radiation portal. We retrospectively analyzed the clinical data of 78 M-NSCLC patients who received single-dose 8-Gy CRI for painful TF after concurrent chemoradiation therapy to a total radiation dose of 52 to 66 Gy between 2007 and 2012. Primary endpoints included significant pain relief (SPR) defined as a ≥2 point decrement in the Visual Analogue Scale for Pain inventory (VAS-P), time to pain relief, and duration of pain control. Secondary objectives were survival and prognostic factors. Treatment was well tolerated, with only 5.1% grade 3 pneumonitis and 1.3% grade 2 esophagitis. Pre-CRI median and post-CRI minimum VAS-P were 7 and 3 (P<.001), respectively. SPR was noted in 67 (85.9%) patients, and only 3 (3.9%) scored progressive pain. Median time to lowest VAS-P and duration of pain control were 27 days and 6.1 months, respectively. Median overall survival (OS) was 7.7 months, and the 1-year OS rate was 26.5%. On multivariate analyses, lower Eastern Cooperative Oncology group score (1-2; P<.001), absence of anemia...Continue Reading

References

Dec 1, 1993·American Journal of Clinical Oncology·J F MontebelloF W Peyton
Oct 16, 1999·American Journal of Clinical Oncology·S J Martins, J R Pereira
Apr 25, 2000·American Journal of Clinical Oncology·E L GressenW J Curran
Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Yoshiaki OkamotoYasumasa Kuroda
May 29, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jean Potter, Irene J Higginson
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gijsbert W P M KramerJan-Willem H Leer
Dec 21, 2006·Journal of the National Cancer Institute·Wilbert B van den HoutJan-Willem H Leer
Aug 12, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Erkan TopkanAli Aydin Yavuz
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alysa FairchildEdward Chow
Nov 27, 2008·Journal of Medical Imaging and Radiation Oncology·J I TangM F Back
Apr 13, 2010·International Journal of Radiation Oncology, Biology, Physics·Patrick KellyJoe Y Chang
Apr 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Branislav Jeremić, Gregory M M Videtic
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Jan 29, 2014·International Journal of General Medicine·Susannah K LeeMustafa Ba Djamgoz
Mar 29, 2014·Current Opinion in Supportive and Palliative Care·Nicholas GoughMark Linch
Oct 12, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J MaguireM Snee

❮ Previous
Next ❯

Citations

May 20, 2017·Clinical Journal of Oncology Nursing·Linda H EatonChao Yeh
Dec 3, 2016·Molecular and Clinical Oncology·Miki KikuchiHiroaki Satoh
Apr 21, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Matthew S NingMary Frances McAleer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.