Abstract
To investigate the safety and efficacy of single-dose 8-Gy palliative chest reirradiation (CRI) in metastatic non-small cell lung cancer (M-NSCLC) patients with painful thoracic failures (TF) within the previous radiation portal. We retrospectively analyzed the clinical data of 78 M-NSCLC patients who received single-dose 8-Gy CRI for painful TF after concurrent chemoradiation therapy to a total radiation dose of 52 to 66 Gy between 2007 and 2012. Primary endpoints included significant pain relief (SPR) defined as a ≥2 point decrement in the Visual Analogue Scale for Pain inventory (VAS-P), time to pain relief, and duration of pain control. Secondary objectives were survival and prognostic factors. Treatment was well tolerated, with only 5.1% grade 3 pneumonitis and 1.3% grade 2 esophagitis. Pre-CRI median and post-CRI minimum VAS-P were 7 and 3 (P<.001), respectively. SPR was noted in 67 (85.9%) patients, and only 3 (3.9%) scored progressive pain. Median time to lowest VAS-P and duration of pain control were 27 days and 6.1 months, respectively. Median overall survival (OS) was 7.7 months, and the 1-year OS rate was 26.5%. On multivariate analyses, lower Eastern Cooperative Oncology group score (1-2; P<.001), absence of anemia...Continue Reading
References
Dec 1, 1993·American Journal of Clinical Oncology·J F MontebelloF W Peyton
Jan 1, 1997·Pain·S Mercadante
Oct 16, 1999·American Journal of Clinical Oncology·S J Martins, J R Pereira
Apr 25, 2000·American Journal of Clinical Oncology·E L GressenW J Curran
Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Yoshiaki OkamotoYasumasa Kuroda
Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Kai-Liang WuShen Zhao
May 29, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jean Potter, Irene J Higginson
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gijsbert W P M KramerJan-Willem H Leer
Dec 21, 2006·Journal of the National Cancer Institute·Wilbert B van den HoutJan-Willem H Leer
Aug 12, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Erkan TopkanAli Aydin Yavuz
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alysa FairchildEdward Chow
Nov 27, 2008·Journal of Medical Imaging and Radiation Oncology·J I TangM F Back
Apr 13, 2010·International Journal of Radiation Oncology, Biology, Physics·Patrick KellyJoe Y Chang
Apr 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Branislav Jeremić, Gregory M M Videtic
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Apr 27, 2013·Radiation Oncology·Marsha ReyngoldAndreas Rimner
Sep 17, 2013·International Journal of Radiation Oncology, Biology, Physics·Erkan TopkanUgur Selek
Jan 29, 2014·International Journal of General Medicine·Susannah K LeeMustafa Ba Djamgoz
Mar 29, 2014·Current Opinion in Supportive and Palliative Care·Nicholas GoughMark Linch
Jul 1, 2014·Cancer Science·Jie-Tao MaQi-Yong Guo
Oct 12, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J MaguireM Snee
Citations
May 20, 2017·Clinical Journal of Oncology Nursing·Linda H EatonChao Yeh
Mar 15, 2019·Radiation Oncology·Jianjiao NiZhengfei Zhu
Dec 3, 2016·Molecular and Clinical Oncology·Miki KikuchiHiroaki Satoh
Apr 21, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Matthew S NingMary Frances McAleer