PMID: 15366326Sep 16, 2004Paper

Safety and pharmacokinetics of inhaled morphine delivered using the AERx system in patients with moderate-to-severe asthma

International Journal of Clinical Pharmacology and Therapeutics
Babatunde A OtulanaJohn B Thipphawong

Abstract

The safety and pharmacokinetics of inhaled morphine in asthmatic subjects were investigated using the AERx System, a novel aerosol system. Twenty subjects with asthma received inhaled placebo and inhaled morphine sulfate, 2.2 mg, 4.4 mg and 8.8 mg, on separate days in a single-blind crossover study. Six of the subjects received an additional open-label dose of 17.6 mg on a separate day. Plasma morphine concentrations and safety evaluations including pulmonary function testing were performed. Mean tmax values were similar following all dose groups at approximately 1-2 minutes. Mean AUC(0-->1) values showed dose proportionality for the first 3 dose groups (6.3, 12.3 and 24.3 ng x h x ml(-1)), the mean AUC(0-->1) for the 17.6 mg dose group was 1.6x that of the 8.8 mg dose group. No statistically significant differences in forced expiratory volume in 1 sec (FEV1) were found for the 2.2 mg, 4.4 mg, or 8.8 mg dose groups; at 17.6 mg, a statistically significant but not clinically meaningful reduction in mean FEV1 (-8.18%) from baseline occurred at 10 minutes compared to placebo, spontaneously returning to baseline by 60 min. Four subjects experienced significant but reversible decreases in FEV1 of > or = 20% compared to baseline and ...Continue Reading

Citations

Mar 23, 2011·Pharmaceutical Research·Elizabeth Rosado BalmayorRui L Reis
Jul 10, 2007·Diabetes Technology & Therapeutics·Joseph D Brain
Dec 8, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jeffry G WeersIan J Smith
Apr 28, 2010·Expert Review of Neurotherapeutics·Mellar P Davis
Oct 31, 2006·Advanced Drug Delivery Reviews·Stephen J Farr, Babatunde A Otulana
Oct 7, 2006·Advanced Drug Delivery Reviews·John Thipphawong
Apr 1, 2005·Drug Discovery Today. Technologies·Henderik W Frijlink, Anne H de Boer
Apr 12, 2016·The Journal of Pharmacy and Pharmacology·Thiago C Carvalho, Jason T McConville
Nov 24, 2017·The European Respiratory Journal·Cindy A VerberktDaisy J A Janssen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.