Safety and Short-Term Efficacy of Irreversible Electroporation and Allogenic Natural Killer Cell Immunotherapy Combination in the Treatment of Patients with Unresectable Primary Liver Cancer

Cardiovascular and Interventional Radiology
Yumei YangJibing Chen

Abstract

This study aimed to investigate the safety and short-term efficacy of irreversible electroporation (IRE) combined with allogenic natural killer (NK) cell immunotherapy in the treatment of patients with unresectable primary liver cancer. Between October 2015 and December 2016, 40 patients were enrolled and randomly allocated to either the IRE group (n = 22) or the IRE-NK group (n = 18). All adverse events experienced by the patients were recorded; the changes in tumor biomarkers [AFP, CA 19-9, circulating tumor cells (CTCs)], lymphocyte number and function, quality of life, clinical response, progression-free survival (PFS) and overall survival (OS) were assessed. Patients who received combination therapy exhibited significantly longer median PFS and OS than who just received IRE (PFS 15.1 vs. 10.6 months, P < 0.05, OS 17.9 vs. 23.2 months, P < 0.05). The combination therapy of IRE and NK cell immunotherapy significantly reduced CTCs and increased immune function and Karnofsky performance status. Our data suggest a novel, promising combination therapy using IRE and allogenic NK cell immunotherapy. Larger clinical trials are required to confirm these conclusions.

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Citations

Oct 17, 2019·Cancers·Sooyeon OhSang-Woon Choi
Jul 30, 2020·Radiology and Oncology·Tamara PolajzerDamijan Miklavcic
Jan 31, 2019·Cardiovascular and Interventional Radiology·Naveen KalraNiranjan Khandelwal
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Jul 28, 2020·Clinics and Research in Hepatology and Gastroenterology·Jing WangLinwei Zhang
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Feb 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yuanlin WuZhangang Xiao
Nov 17, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Luo WangPing Liang

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Methods Mentioned

BETA
surgical resection
flow cytometry

Clinical Trials Mentioned

NCT03008343

Software Mentioned

GraphPad Prism
mRECIST
SPSS

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