Abstract
Artemisinin combination therapy has become the standard of care for uncomplicated malaria in most of Africa. However, there is limited data on the safety and tolerability of these drugs, especially in young children and patients co-infected with HIV. A longitudinal, randomized controlled trial was conducted in a cohort of HIV-infected and uninfected children aged 4-22 months in Tororo, Uganda. Participants were randomized to treatment with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) upon diagnosis of their first episode of uncomplicated malaria and received the same regimen for all subsequent episodes. Participants were actively monitored for adverse events for 28 days and then passively for up to 63 days after treatment. This study was registered in ClinicalTrials.gov (registration # NCT00527800). A total of 122 children were randomized to AL and 124 to DP, resulting in 412 and 425 treatments, respectively. Most adverse events were rare, with only cough, diarrhoea, vomiting, and anaemia occurring in more than 1% of treatments. There were no differences in the risk of these events between treatment groups. Younger age was associated with an increased risk of diarrhoea in both the AL and DP treatment arms...Continue Reading
References
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R BakshiE Alteri
Apr 27, 2005·Lancet·Theonest K MutabingwaChristopher J M Whitty
Oct 20, 2005·The Cochrane Database of Systematic Reviews·A A A OmariP Garner
Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Corine KaremaUmberto D'Alessandro
Jun 20, 2006·Malaria Journal·Ambrose O TalisunaUmberto D'Alessandro
Jul 28, 2006·PLoS Clinical Trials·Hasifa BukirwaSarah G Staedke
Aug 15, 2006·Tropical Medicine & International Health : TM & IH·M MayxayP N Newton
Sep 29, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·C I FanelloU D'Alessandro
May 24, 2007·JAMA : the Journal of the American Medical Association·Grant DorseyPhilip J Rosenthal
May 26, 2007·PLoS Clinical Trials·Moses R KamyaGrant Dorsey
Jul 31, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·H Y MyintN J White
Sep 18, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ushma MehtaKaren I Barnes
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Issaka ZongoJean Bosco Ouédraogo
Jan 9, 2008·Antimicrobial Agents and Chemotherapy·J TarningN J White
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne F GasasiraGrant Dorsey
Jun 12, 2008·PloS One·Adoke YekaHasifa Bukirwa
Jun 13, 2008·Malaria Journal·Catherine Maiteki-SebuguziSarah G Staedke
Jun 13, 2008·Malaria Journal·Sarah G StaedkeAmbrose O Talisuna
Aug 21, 2008·The Journal of Infectious Diseases·Kelly E DooleyAdriana S Andrade
Jun 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Polina GermanFrancesca T Aweeka
Nov 3, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emmanuel ArinaitweGrant Dorsey
Citations
Jul 12, 2011·Malaria Journal·Hervé MenanMoussa Kone
Jan 1, 2013·Malaria Journal·Prasanna JagannathanGrant Dorsey
Nov 2, 2013·Malaria Journal·Oluwaseun Egunsola, Kazeem A Oshikoya
Jan 15, 2014·PLoS Pathogens·Prasanna JagannathanMargaret E Feeney
Dec 12, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Cho NaingJadon Y R Wong
Jul 22, 2014·Malaria Research and Treatment·Wisdom Akpaloo, Edward Purssell
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Humphrey WanziraGrant Dorsey
Sep 23, 2014·Malaria Journal·George O AdjeiJorgen A Kurtzhals
Apr 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abel KakuruGrant Dorsey
Feb 6, 2013·The American Journal of Tropical Medicine and Hygiene·Abel KakuruGrant Dorsey
Mar 5, 2016·Malaria Journal·Richard T SullivanRichard Sullivan
Aug 12, 2014·Expert Opinion on Pharmacotherapy·Benjamin J VisserMartin P Grobusch
Jun 8, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Tina Ming-Na LeeSunil Parikh
Feb 6, 2015·Malaria Journal·James KapisiGrant Dorsey
Aug 19, 2014·PloS One·Issaka ZongoJean Bosco Ouédraogo
Apr 13, 2012·The Annals of Pharmacotherapy·Kayla R StoverJessica Robinson
Jan 21, 2014·The Cochrane Database of Systematic Reviews·Babalwa ZaniDavid Sinclair
Jan 27, 2018·Malaria Journal·Francesco GrandessoJean-François Etard
Sep 14, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elaine J AbramsAndrea J Ruff
Dec 19, 2018·Malaria Journal·Humphrey WanziraAdoke Yeka
Dec 6, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shirin HeidariElly Katabira
Apr 3, 2021·Malaria Journal·Dawit Getachew AssefaTsegahun Manyazewal
Jun 28, 2011·The Lancet Infectious Diseases·Clara FlateauGilles Pialoux