Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children.

Malaria Journal
Shereen KatrakGrant Dorsey

Abstract

Artemisinin combination therapy has become the standard of care for uncomplicated malaria in most of Africa. However, there is limited data on the safety and tolerability of these drugs, especially in young children and patients co-infected with HIV. A longitudinal, randomized controlled trial was conducted in a cohort of HIV-infected and uninfected children aged 4-22 months in Tororo, Uganda. Participants were randomized to treatment with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) upon diagnosis of their first episode of uncomplicated malaria and received the same regimen for all subsequent episodes. Participants were actively monitored for adverse events for 28 days and then passively for up to 63 days after treatment. This study was registered in ClinicalTrials.gov (registration # NCT00527800). A total of 122 children were randomized to AL and 124 to DP, resulting in 412 and 425 treatments, respectively. Most adverse events were rare, with only cough, diarrhoea, vomiting, and anaemia occurring in more than 1% of treatments. There were no differences in the risk of these events between treatment groups. Younger age was associated with an increased risk of diarrhoea in both the AL and DP treatment arms...Continue Reading

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Citations

Jan 15, 2014·PLoS Pathogens·Prasanna JagannathanMargaret E Feeney
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Humphrey WanziraGrant Dorsey
Apr 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abel KakuruGrant Dorsey
Feb 6, 2013·The American Journal of Tropical Medicine and Hygiene·Abel KakuruGrant Dorsey
Mar 5, 2016·Malaria Journal·Richard T SullivanRichard Sullivan
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