Safety and tolerability of calcitonin-gene-related peptide binding monoclonal antibodies for the prevention of episodic migraine - a meta-analysis of randomized controlled trials

Cephalalgia : an International Journal of Headache
Da XuLing Liu

Abstract

To systematically evaluate the safety and tolerability of calcitonin-gene-related peptide binding monoclonal antibodies from the results of randomized controlled trials. Online databases were searched on calcitonin-gene-related peptide binding monoclonal antibodies for the prevention of episodic migraine. Overall withdrawal, withdrawal due to adverse events, adverse events, serious adverse events and specific adverse events were extracted from the included studies. A meta-analysis was performed with Revman 5.3.0 software. Ten studies that investigated four drugs (galcanezumab, erenumab, fremanezumab and eptinezumab) with 5817 participants were included in this study. Serious adverse events, overall withdrawals, withdrawal due to adverse events and any adverse events were not significantly associated with monoclonal antibody treatment. Injection site pain and erythema were significantly higher in the calcitonin-gene-related peptide binding monoclonal antibodies treatment group than in the placebo group. The rates of serious adverse events were significantly higher in the galcanezumab 120 mg group. Injection site erythema was associated with galcanezumab 120 mg and 240 mg. Injection site pain and nasopharyngitis were associated w...Continue Reading

References

Mar 12, 2004·The New England Journal of Medicine·Jes OlesenUNKNOWN BIBN 4096 BS Clinical Proof of Concept Study Group
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 8, 2010·Nature Reviews. Neurology·Tony W HoPeter J Goadsby
Jan 12, 2013·Cephalalgia : an International Journal of Headache·T J SteinerG L Birbeck
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Nov 25, 2017·The New England Journal of Medicine·Peter J GoadsbyRobert A Lenz
Dec 12, 2017·Expert Opinion on Drug Metabolism & Toxicology·Abimael González-HernándezCarlos M Villalón
Feb 24, 2018·Cephalalgia : an International Journal of Headache·David W DodickRobert A Lenz
May 26, 2018·JAMA : the Journal of the American Medical Association·David W DodickErnesto Aycardi
Jun 1, 2018·Cephalalgia : an International Journal of Headache·Vladimir SkljarevskiJyun Yan Yang
Jul 4, 2018·Drugs·Anthony Markham

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Citations

Sep 27, 2019·CNS Drugs·Calvin Chan, Peter J Goadsby
Jun 19, 2019·International Journal of Molecular Sciences·Giuseppe TardioloEmanuela Mazzon
Mar 31, 2020·Pain and Therapy·Ivan UritsOmar Viswanath
Jun 12, 2020·Therapeutic Advances in Neurological Disorders·Anna P AndreouGiorgio Lambru
Jan 11, 2020·Frontiers in Neurology·P Ashley WackymJasdeep S Hundal
Mar 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Alicia AlpuentePatricia Pozo-Rosich
Apr 15, 2021·Current Opinion in Neurology·Linda Al-Hassany, Antoinette MaassenVanDenBrink
Jul 19, 2021·The Journal of Headache and Pain·Robert BelvísMargarita Sánchez Del Río

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Clinical Trials Mentioned

NCT02985398
NCT02974153
NCT02559895

Software Mentioned

Ovid
Review Manager
Cochrane

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