Safety and tolerability of etravirine

Enfermedades infecciosas y microbiología clínica
Joaquín Portilla

Abstract

Etravirine (ETR) is the first representative of a new generation of non-nucleoside reverse transcriptase inhibitors (NNRTI) and is indicated in patients with HIV infection and virological failure. The recommended dose is 200 mg (two tablets) every 12 hours after a meal. ETR has good tolerability and the tablets can be dissolved in water, which can aid swallowing in some patients. This drug has a plasma half-life of 30-40 hours and consequently is a candidate for once-daily regimens. The most frequent adverse effect is rash (affecting 19% of patients), which is usually mild (grades 1 or 2) and does not lead to drug withdrawal. The DUET 1 and 2 studies, which compared ETR versus placebo, with both groups receiving boosted darunavir and an optimized background regimen, did not demonstrate a higher incidence of liver toxicity, neuropsychiatric symptoms, gastrointestinal disturbances or atherogenic dyslipidemia in patients receiving ETR. The safety profile of ETR suggests that it could be used as a substitute drug in patients with toxicity induced by first-generation NNRTIs or other antiretroviral drugs.

References

Jan 11, 2001·Drugs·L J Scott, C M Perry
Jul 27, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J BlanchJ M Gatell
May 18, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valérie JournotUNKNOWN ALIZE Study Group
May 3, 2007·European Journal of Clinical Pharmacology·Elena ArroyoEsperanza Merino
May 7, 2009·AIDS·Richard H HaubrichUNKNOWN AIDS Clinical Trials Group (ACTG) A5142 Study Team
Jun 25, 2009·Expert Opinion on Investigational Drugs·Lucy Garvey, Alan Winston

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Citations

Dec 14, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Stacy D FisherSteven E Lipshultz

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