PMID: 16644619Apr 29, 2006Paper

Safety and tolerance of ester-C compared with regular ascorbic acid

Advances in Therapy
Joerg GruenwaldChristine Bentley

Abstract

The goal of this randomized, double-blind crossover clinical trial in 50 healthy volunteers sensitive to acidic foods was to evaluate whether Ester-C calcium ascorbate causes fewer epigastric adverse effects than are produced by regular ascorbic acid (AA). Volunteers were randomly separated into 2 groups of 25. The study comprised an observation period of 9 days (phase 1 medication for 3 consecutive days, washout phase for 3 consecutive days, phase 2 medication for 3 consecutive days). Participants took 1000 mg vitamin C as Ester-C during phase 1 of the study followed by 1000 mg of vitamin C as AA during phase 2, or vice versa. During the course of the study, 3 examinations for the evaluation of epigastric adverse effects were performed (on days 0, 3, and 9). Participants used a diary to record epigastric adverse effects on a daily basis. In total, 28 (56%) of 50 participants reported 88 epigastric adverse effects of mild to moderate intensity. Of these 88 adverse effects, 33 (37.5%) occurred after intake of Ester-C and 55 (62.5%) were noted after intake of AA. The tolerability of Ester-C was rated "very good" by 72% of participants, whereas AA was rated "very good" by only 54%. This difference is statistically significant (P<....Continue Reading

References

Jan 1, 1992·The British Journal of Nutrition·H Hemilä
Apr 1, 1995·Journal of the American College of Nutrition·H Hemilä, Z S Herman
Jan 1, 1997·The British Journal of Nutrition·H Hemilä
Feb 15, 2001·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·P Jernigan, D L Andress
Nov 10, 2001·The Medical Journal of Australia·C AuderaR M Douglas
Aug 31, 2002·Advances in Therapy·Michael Van Straten, Peter Josling
Apr 26, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Bruce W Hollis, Carol L Wagner

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Citations

Oct 31, 2013·Nutrients·Anitra C Carr, Margreet C M Vissers
Jul 29, 2017·Experimental Biology and Medicine·Edwin D Lephart, Merritt B Andrus
Jan 6, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Joon-Kyung LeeChang-Seon Myung

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