Safety assessment of anticancer drugs in association with radiotherapy in metastatic malignant melanoma: a real-life report : Radiation/systemic drug combo in metastatic melanoma

Cancer Chemotherapy and Pharmacology
Emmanuelle CoutyNicolas Magné

Abstract

To assess the safety of the association of radiotherapy (RT) and systemic treatments for patients with metastatic malignant melanoma (mMM). A retrospective analysis included consecutive patients treated with palliative RT, and at least one line of systemic therapy for mMM between 2001 and 2016. Treatments were defined as sequential or concomitant when RT and the systemic drug were administered, respectively, at more or less than five half-lives from each other. 92 patients were included. They had 110 palliative RT treatments. RT was delivered with a "conventional" chemotherapy (mainly fotemustine and/or dacarbazine) and a "modern" systemic therapy (BRAF inhibitors, association of BRAF and MEK inhibitors, immunotherapy), respectively, in 88 (80%) and 22 (20%) cases. Systemic treatments and RT were mainly concurrently performed (n = 61, 55.5%). Regarding acute grade ≥ 3 toxicity, no difference was reported between sequential and concomitant groups either in the whole cohort (p = 1) or in the subgroup of patients receiving "modern" systemic therapies (p = 1). Acute and late grade ≥ 3 toxicities only occurred with vemurafenib. BRAF inhibitors and RT produced more severe infield adverse events than other associations (p = 0.001) wit...Continue Reading

References

Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Feb 8, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maria J SambadeJaniel M Shields
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 26, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stephanie Du FourBart Neyns
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B Ashleigh GuadagnoloYa-Chen Tina Shih
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Imke SatzgerRalf Gutzmer
Apr 13, 2013·Journal of Neuro-oncology·Ashwatha NarayanaAnna C Pavlick
May 8, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher J AnkerKenneth F Grossmann
May 24, 2013·JAMA Dermatology·Lise BoussemartCaroline Robert
Nov 7, 2013·European Journal of Dermatology : EJD·Lucie PeuvrelBrigitte Dreno
Dec 24, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·B SchulzeC Weiss
Mar 29, 2014·Practical Radiation Oncology·Thomas M ChurillaMichael A Lacombe
Apr 30, 2014·Cancer Immunology Research·Christopher A BarkerJedd D Wolchok
May 17, 2014·Journal of the American Academy of Dermatology·Michael Saco, Christina Mitchell
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Trish PulvirentiWei Wang
Jun 27, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ricarda MertenSabine Semrau
Jul 24, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J ThariatF Mornex
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertDirk Schadendorf
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Jan 15, 2015·Radiation Oncology·Marie-Adele Sorel KressArnold L Potosky
Feb 20, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Melek Karakurt EryılmazHasan Şenol Coşkun
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Ana P KiessKathryn Beal
Mar 13, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M HechtL Heinzerling
Dec 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K A AhmedG T Gibney
May 1, 2016·International Journal of Radiation Oncology, Biology, Physics·Christopher J AnkerJohn M Kirkwood
Jun 23, 2016·Gynecologic Oncology Reports·Maria B SchiavoneMario M Leitao
Jul 2, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC)
Aug 9, 2016·Journal of the National Comprehensive Cancer Network : JNCCN·Daniel G CoitAnita Engh
Jan 23, 2017·Critical Reviews in Oncology/hematology·Sophie EspenelNicolas Magné
Jan 26, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·B GuillotR Vanwijck
Sep 12, 2018·Advances in Radiation Oncology·Neha P AminMalcolm D Mattes
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M HechtL Heinzerling

❮ Previous
Next ❯

Citations

Feb 15, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jeongshim LeeSang Joon Shin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.