Safety assessment of aqueous olive pulp extract as an antioxidant or antimicrobial agent in foods

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M G SoniRoberto Crea

Abstract

The olive fruit, its oil and the leaves of the olive tree have a rich history of nutritional, medicinal and ceremonial uses. Olive oil, table olives and olive products are an important part of the Mediterranean diet, the greatest value of which may be due to olive polyphenols that contribute to the modulation of the oxidative balance in vivo. The objective of this review is to examine the available safety/toxicity literature on olive polyphenols, particularly hydroxytyrosol, to determine the safety-in-use of a standardized aqueous olive pulp extract (HIDROX). Among the polyphenols found in the extract, the major constituent of biological significance is hydroxytyrosol (50-70%). In oral bioavailability studies, urinary excretion of hydroxytyrosol and its glucuronide was found to be associated with the intake of hydroxytyrosol. Oral bioavailability of hydroxytyrosol in olive oil and in an aqueous solution was reported as 99% and 75%, respectively. In comparative studies, urinary excretion of hydroxytyrosol was greater in humans than in rats. The LD(50) of the extract and hydroxytyrosol was reported to be greater than 2000 mg/kg. In a subchronic study, the no observed adverse effect level (NOAEL) of the extract in rats was found t...Continue Reading

References

May 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M SalamiF Visioli
Jan 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R AeschbachO I Aruoma
Oct 1, 1995·The Journal of Applied Bacteriology·R CapassoG Cristinzio
Jun 11, 1998·Phytochemistry·J J Salas, J Sánchez
Jun 24, 1998·Biochemical and Biophysical Research Communications·F VisioliC Galli
Feb 5, 1999·Biochemical Pharmacology·R de la PuertaJ R Hoult
Sep 30, 1999·The Journal of Pharmacy and Pharmacology·G BisignanoA Saija
Feb 29, 2000·FEBS Letters·F VisioliD Caruso
Sep 29, 2000·Analytical Chemistry·V Ruiz-GutiérrezJ M Planas
Nov 30, 2000·Biochemical and Biophysical Research Communications·F D RagioneV Zappia
May 23, 2001·Journal of Agricultural and Food Chemistry·N PellegriniF Brighenti
Dec 6, 2001·Metabolism: Clinical and Experimental·D CarusoG Galli
Dec 18, 2001·Medicinal Research Reviews·Francesco VisioliClaudio Gall
Apr 4, 2002·Journal of Agricultural and Food Chemistry·Kellie L TuckIeva Stupans
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Georgios BlekasDimitrios G Boskou
Aug 27, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·R FabianiG Morozzi
Oct 17, 2002·Journal of Agricultural and Food Chemistry·Caterina MannaVincenzo Zappia
Oct 31, 2002·Journal of Agricultural and Food Chemistry·Juan Fernández-BolañosAna Jiménez
Dec 17, 2002·FEBS Letters·Fulvio Della RagioneVincenzo Zappia
Jan 28, 2003·European Journal of Clinical Nutrition·E Miró-CasasR de la Torre
Jan 29, 2003·The Journal of Nutritional Biochemistry·Kellie L. Tuck, Peter J. Hayball
Mar 28, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R W OwenH Bartsch
May 27, 2003·Clinical Chemistry·Elisabet Miro-CasasRafael de la Torre
Feb 5, 2004·Journal of Agricultural and Food Chemistry·Concepción RomeroAntonio Garrido
Nov 13, 2004·The Journal of Nutritional Biochemistry·C MannaV Zappia
Dec 3, 2004·Drug and Chemical Toxicology·Mildred S ChristianRoberto Crea

❮ Previous
Next ❯

Citations

Sep 21, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Aristotelis KotronoulasRafael de la Torre
May 19, 2012·Journal of Agricultural and Food Chemistry·Giuseppe RistagnoRoberto Bianchi
Sep 6, 2012·European Journal of Clinical Nutrition·H E BaysJ W Anderson
Jan 7, 2014·Analytical and Bioanalytical Chemistry·María Vergara-BarberánErnesto Francisco Simó-Alfonso
Jun 8, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Ahmed TafeshHassan Azaizeh
Nov 13, 2009·Nutrition Reviews·Sedef N El, Sibel Karakaya
Apr 27, 2010·Nutrition Reviews·Sergio Granados-PrincipalM Carmen Ramirez-Tortosa
Jul 14, 2007·Journal of Colloid and Interface Science·A Y El-Etre
Jul 18, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jacqueline HeilmanJosé López
Sep 23, 2014·Food Chemistry·M Vergara-BarberánE F Simó-Alfonso
Feb 6, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David Auñon-CallesFrancesco Visioli
Mar 3, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·David KirklandPaul Beilstein
Jul 10, 2016·Archives of Medical Research·Jaouad AnterAntonio Casado-Díaz
Sep 18, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana Paula PereiraJosé Alberto Pereira
Jul 1, 2017·Critical Reviews in Food Science and Nutrition·Nicola CaporasoAlessandro Genovese
Dec 15, 2015·International Journal of Toxicology·Amy E ClewellIlona Pasics Szakonyiné
May 17, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A VoltesF de la Portilla
Mar 2, 2019·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Damian H GillingKelly R Bright
Sep 11, 2019·Nutrients·Avilene Rodríguez-LaraJesús R Huertas
Sep 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amalia D KalampalikiIoannis K Kostakis
Feb 5, 2014·Journal of Food Protection·Chayapa TechathuvananP Michael Davidson
Jun 10, 2019·Applied Microbiology and Biotechnology·James BrittonKevin E O'Connor
Jun 4, 2020·International Journal of Molecular Sciences·Gabriele Di RosaNadine Saul
Oct 1, 2020·Food Science & Nutrition·Arshad MehmoodChengtao Wang
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lamia Singer, Christoph P Bourauel
Jan 8, 2021·Arhiv za higijenu rada i toksikologiju·Marina Bubonja-ŠonjeMaja Abram
Mar 12, 2020·Food Research International·Coralie DupasEmilie Dumas
Feb 18, 2009·Journal of Agricultural and Food Chemistry·Francesco VisioliRoberto Crea
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefania BalzanLuca Fasolato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Related Papers

The Journal of Pharmacy and Pharmacology
Giuseppe BisignanoA Saija
Journal of Agricultural and Food Chemistry
A RomaniA Cimato
Clinical Chemistry
Elisabet Miró-CasasRafael de la Torre
Journal of Agricultural and Food Chemistry
M Esti La Notte E
© 2021 Meta ULC. All rights reserved